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Items: 1 to 20 of 23

1.

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.

Majumdar S, Grinnell S, Le Rouzic V, Burgman M, Polikar L, Ansonoff M, Pintar J, Pan YX, Pasternak GW.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19778-83. doi: 10.1073/pnas.1115231108. Epub 2011 Nov 21.

2.

Opioids and their receptors: Are we there yet?

Pasternak GW.

Neuropharmacology. 2014 Jan;76 Pt B:198-203. doi: 10.1016/j.neuropharm.2013.03.039. Epub 2013 Apr 26. Review.

3.

Mu opioid receptors in pain management.

Pasternak G, Pan YX.

Acta Anaesthesiol Taiwan. 2011 Mar;49(1):21-5. doi: 10.1016/j.aat.2010.12.008. Epub 2011 Mar 17. Review.

4.

Mu opioid receptor regulation and opiate responsiveness.

Raehal KM, Bohn LM.

AAPS J. 2005 Oct 19;7(3):E587-91. Review.

5.

Designing Safer Analgesics via μ-Opioid Receptor Pathways.

Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S.

Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/j.tips.2017.08.004. Epub 2017 Sep 19. Review.

6.

The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence.

Bao Y, Gao Y, Yang L, Kong X, Yu J, Hou W, Hua B.

Channels (Austin). 2015;9(5):235-43. doi: 10.1080/19336950.2015.1069450. Epub 2015 Jul 15. Review.

7.

Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology.

Whistler JL.

Drug Alcohol Depend. 2012 Mar 1;121(3):189-204. doi: 10.1016/j.drugalcdep.2011.10.031. Epub 2012 Jan 9. Review.

8.

μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids.

Convertino M, Samoshkin A, Gauthier J, Gold MS, Maixner W, Dokholyan NV, Diatchenko L.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:61-7. doi: 10.1016/j.pnpbp.2014.11.009. Epub 2014 Dec 6. Review.

9.

β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.

Raehal KM, Bohn LM.

Handb Exp Pharmacol. 2014;219:427-43. doi: 10.1007/978-3-642-41199-1_22. Review.

10.

The pharmacology of mu analgesics: from patients to genes.

Pasternak GW.

Neuroscientist. 2001 Jun;7(3):220-31. Review.

PMID:
11499401
11.

Opioid-induced redistribution of 6TM and 7TM μ opioid receptors: A hypothesized mechanistic facilitator model of opioid-induced hyperalgesia.

Wang W, Wang Y, Zhang W, Jin X, Liu Y, Xu S, Lei L, Shen X, Guo X, Xia X, Wang F.

Pharmacol Rep. 2016 Aug;68(4):686-91. doi: 10.1016/j.pharep.2016.03.003. Epub 2016 Mar 19. Review.

PMID:
27116700
12.

Is there genetic polymorphism evidence for individual human sensitivity to opiates?

Nagashima M, Katoh R, Sato Y, Tagami M, Kasai S, Ikeda K.

Curr Pain Headache Rep. 2007 Apr;11(2):115-23. Review.

PMID:
17367590
13.

Mu opioids and their receptors: evolution of a concept.

Pasternak GW, Pan YX.

Pharmacol Rev. 2013 Sep 27;65(4):1257-317. doi: 10.1124/pr.112.007138. Print 2013. Review.

14.

Recent advances in endomorphin engineering.

Keresztes A, Borics A, Tóth G.

ChemMedChem. 2010 Aug 2;5(8):1176-96. doi: 10.1002/cmdc.201000077. Review.

PMID:
20491136
15.

Molecular biology of opioid analgesia.

Pasternak GW.

J Pain Symptom Manage. 2005 May;29(5 Suppl):S2-9. Review.

PMID:
15907642
16.

What is the main mechanism of tramadol?

Minami K, Ogata J, Uezono Y.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):999-1007. doi: 10.1007/s00210-015-1167-5. Epub 2015 Aug 21. Review.

PMID:
26292636
17.

Multitarget opioid ligands in pain relief: New players in an old game.

Turnaturi R, Aricò G, Ronsisvalle G, Parenti C, Pasquinucci L.

Eur J Med Chem. 2016 Jan 27;108:211-228. doi: 10.1016/j.ejmech.2015.11.028. Epub 2015 Nov 22. Review.

PMID:
26656913
18.

Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.

Oladosu FA, Maixner W, Nackley AG.

Mayo Clin Proc. 2015 Aug;90(8):1135-51. doi: 10.1016/j.mayocp.2015.06.010. Review.

19.

Opioid receptors: toward separation of analgesic from undesirable effects.

Law PY, Reggio PH, Loh HH.

Trends Biochem Sci. 2013 Jun;38(6):275-82. doi: 10.1016/j.tibs.2013.03.003. Epub 2013 Apr 16. Review.

20.

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