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Items: 17

1.

Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.

Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, Qadri A, Gareski T, Jones J, Hahm S, Perreault M, McKew J, Shi M, Xu X, Tobin JF, Gimeno RE.

J Biol Chem. 2011 Dec 2;286(48):41838-51. doi: 10.1074/jbc.M111.245456. Epub 2011 Oct 11.

2.

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.

Chen HC, Farese RV Jr.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):482-6. Epub 2004 Nov 29. Review.

3.

Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors.

DeVita RJ, Pinto S.

J Med Chem. 2013 Dec 27;56(24):9820-5. doi: 10.1021/jm4007033. Epub 2013 Sep 3. Review.

PMID:
23919406
4.

DGAT1 inhibitors as anti-obesity and anti-diabetic agents.

Birch AM, Buckett LK, Turnbull AV.

Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96. Review.

PMID:
20597032
5.

Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.

Naik R, Obiang-Obounou BW, Kim M, Choi Y, Lee HS, Lee K.

ChemMedChem. 2014 Nov;9(11):2410-24. doi: 10.1002/cmdc.201402069. Epub 2014 Jun 20. Review.

PMID:
24954424
6.

Glycerolipid acyltransferases in triglyceride metabolism and energy homeostasis-potential as drug targets.

Cao G, Konrad RJ, Li SD, Hammond C.

Endocr Metab Immune Disord Drug Targets. 2012 Jun;12(2):197-206. Review.

PMID:
22385114
7.

DGAT inhibitors for obesity.

Matsuda D, Tomoda H.

Curr Opin Investig Drugs. 2007 Oct;8(10):836-41. Review.

PMID:
17907060
8.

[Progress in the study on diacylgycerol acyltransferase (DGAT)-related genes].

Ma HM, Shi QS, Liu XC.

Yi Chuan Xue Bao. 2005 Dec;32(12):1327-32. Review. Chinese.

PMID:
16459663
9.

Hepatic triglyceride synthesis and nonalcoholic fatty liver disease.

Choi SS, Diehl AM.

Curr Opin Lipidol. 2008 Jun;19(3):295-300. doi: 10.1097/MOL.0b013e3282ff5e55. Review.

PMID:
18460922
10.

Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents.

King AJ, Judd AS, Souers AJ.

Expert Opin Ther Pat. 2010 Jan;20(1):19-29. doi: 10.1517/13543770903499305. Review.

PMID:
20021283
11.

Acyl-CoA:diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology.

Liu Q, Siloto RM, Lehner R, Stone SJ, Weselake RJ.

Prog Lipid Res. 2012 Oct;51(4):350-77. doi: 10.1016/j.plipres.2012.06.001. Epub 2012 Jun 15. Review.

PMID:
22705711
12.

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.

Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV Jr.

J Lipid Res. 2008 Nov;49(11):2283-301. doi: 10.1194/jlr.R800018-JLR200. Epub 2008 Aug 29. Review.

13.

Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism.

Yen CL, Nelson DW, Yen MI.

J Lipid Res. 2015 Mar;56(3):489-501. doi: 10.1194/jlr.R052902. Epub 2014 Sep 17. Review.

14.

[Research progress on diacylgycerol acyltransferase 2 (DGAT2) gene].

Yuan ZR, Liu XC, Ma HM, Ding ZY.

Yi Chuan. 2008 Mar;30(3):289-94. Review. Chinese.

PMID:
18331995
15.

DGAT and triglyceride synthesis: a new target for obesity treatment?

Chen HC, Farese RV Jr.

Trends Cardiovasc Med. 2000 Jul;10(5):188-92. Review.

PMID:
11282293
16.

Allosteric Small Molecule Inhibitors of LMPTP.

Ardecky RJ, Hedrick MP, Stanford SM, Bliss MR, Zou J, Gosalia P, Yamamoto F, Milewski M, Barron N, Sun Q, Ganji S, Mehta A, Sugarman E, Nguyen K, Vasile S, Suyama E, Mangravita-Novo A, Salaniwal S, Kung P, Smith LH, Sergienko E, Chung TDY, Pinkerton AB, Bottini N.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

17.

Inhibitors of Myocyte Triacylglyceride Accumulation.

Hershberger PM, Sugarman E, Maloney P, Peddibhotla S, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Mangravita-Novo A, Smith LH, Soundarapandian MM, Salaniwal S, Kung P, Vega RB, Chung TDY, Pinkerton AB, Malany S, Kelly DP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 15 [updated 2015 Feb 11].

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