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Links from PubMed

Items: 3

1.

Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242).

Verhoest PR, Basak AS, Parikh V, Hayward M, Kauffman GW, Paradis V, McHardy SF, McLean S, Grimwood S, Schmidt AW, Vanase-Frawley M, Freeman J, Van Deusen J, Cox L, Wong D, Liras S.

J Med Chem. 2011 Aug 25;54(16):5868-77. doi: 10.1021/jm2006035. Epub 2011 Jul 22.

PMID:
21744827
2.

Kappa opioid antagonists: past successes and future prospects.

Metcalf MD, Coop A.

AAPS J. 2005 Oct 27;7(3):E704-22. Review.

3.

Systematic characterization of structure-activity relationships and ADMET compliance: a case study.

Yongye AB, Medina-Franco JL.

Drug Discov Today. 2013 Aug;18(15-16):732-9. doi: 10.1016/j.drudis.2013.04.002. Epub 2013 Apr 11. Review.

PMID:
23583765

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