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Items: 1 to 20 of 50

1.

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.

Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189.

2.

Keap1-Nrf2 signalling in pancreatic cancer.

Hayes AJ, Skouras C, Haugk B, Charnley RM.

Int J Biochem Cell Biol. 2015 Aug;65:288-99. doi: 10.1016/j.biocel.2015.06.017. Review.

PMID:
26117456
3.

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress.

Nguyen T, Nioi P, Pickett CB.

J Biol Chem. 2009 May 15;284(20):13291-5. doi: 10.1074/jbc.R900010200. Review.

4.

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.

Tebay LE, Robertson H, Durant ST, Vitale SR, Penning TM, Dinkova-Kostova AT, Hayes JD.

Free Radic Biol Med. 2015 Nov;88(Pt B):108-46. doi: 10.1016/j.freeradbiomed.2015.06.021. Review.

5.

Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.

Villeneuve NF, Lau A, Zhang DD.

Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211. Review.

6.

The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2.

Maher J, Yamamoto M.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):4-15. doi: 10.1016/j.taap.2010.01.011. Review.

PMID:
20122947
7.

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.

Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT.

Antioxid Redox Signal. 2010 Dec 1;13(11):1713-48. doi: 10.1089/ars.2010.3221. Review.

PMID:
20446772
8.

Nrf2: bane or blessing in cancer?

Xiang M, Namani A, Wu S, Wang X.

J Cancer Res Clin Oncol. 2014 Aug;140(8):1251-9. doi: 10.1007/s00432-014-1627-1. Review.

PMID:
24599821
9.

Nrf2 protects against airway disorders.

Cho HY, Kleeberger SR.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):43-56. doi: 10.1016/j.taap.2009.07.024. Review. Erratum in: Toxicol Appl Pharmacol. 2010 Aug 1;246(3):186-7.

PMID:
19646463
10.

Toward clinical application of the Keap1-Nrf2 pathway.

Suzuki T, Motohashi H, Yamamoto M.

Trends Pharmacol Sci. 2013 Jun;34(6):340-6. doi: 10.1016/j.tips.2013.04.005. Review.

PMID:
23664668
11.

Role of the Keap1-Nrf2 pathway in cancer.

Leinonen HM, Kansanen E, Pölönen P, Heinäniemi M, Levonen AL.

Adv Cancer Res. 2014;122:281-320. doi: 10.1016/B978-0-12-420117-0.00008-6. Review.

PMID:
24974185
12.

The complexity of the Nrf2 pathway: beyond the antioxidant response.

Huang Y, Li W, Su ZY, Kong AN.

J Nutr Biochem. 2015 Dec;26(12):1401-13. doi: 10.1016/j.jnutbio.2015.08.001. Review.

13.

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention.

Harder B, Jiang T, Wu T, Tao S, Rojo de la Vega M, Tian W, Chapman E, Zhang DD.

Biochem Soc Trans. 2015 Aug;43(4):680-6. doi: 10.1042/BST20150020. Review.

14.

The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

Copple IM.

Adv Pharmacol. 2012;63:43-79. doi: 10.1016/B978-0-12-398339-8.00002-1. Review.

PMID:
22776639
15.

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation.

Bryan HK, Olayanju A, Goldring CE, Park BK.

Biochem Pharmacol. 2013 Mar 15;85(6):705-17. doi: 10.1016/j.bcp.2012.11.016. Review.

16.
17.

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism.

Chartoumpekis DV, Wakabayashi N, Kensler TW.

Biochem Soc Trans. 2015 Aug;43(4):639-44. doi: 10.1042/BST20150049. Review.

18.

ROS and ROS-Mediated Cellular Signaling.

Zhang J, Wang X, Vikash V, Ye Q, Wu D, Liu Y, Dong W.

Oxid Med Cell Longev. 2016;2016:4350965. doi: 10.1155/2016/4350965. Review.

19.

Estrogen potentiates reactive oxygen species (ROS) tolerance to initiate carcinogenesis and promote cancer malignant transformation.

Tian H, Gao Z, Wang G, Li H, Zheng J.

Tumour Biol. 2016 Jan;37(1):141-50. doi: 10.1007/s13277-015-4370-6. Review.

PMID:
26566628
20.

The paradoxical role of Nrf2 in tumor biology.

Shen H, Zhou S, Wang J.

Crit Rev Eukaryot Gene Expr. 2013;23(1):37-47. Review.

PMID:
23557336

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