Format

Send to

Choose Destination

Links from PubMed

See comment in PubMed Commons below
Fertil Steril. 2011 May;95(6):1950-4, 1954.e1. doi: 10.1016/j.fertnstert.2011.01.151. Epub 2011 Mar 3.

A lower antral follicle count is associated with infertility.

Author information

1
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences: University of California, San Francisco, California 94115, USA. rosenm@obgyn.ucsf.edu

Abstract

OBJECTIVE:

To determine whether infertile women have lower antral follicle counts (AFC) than age-matched normal women.

DESIGN:

Case-control.

SETTING:

Academic center.

PATIENT(S):

A total of 881 infertile women and 771 women from the community.

INTERVENTION(S):

Antral follicle count and basal hormone measurements.

MAIN OUTCOME MEASURE(S):

Median AFCs and FSH levels were compared between the two groups within 5-year age strata by using the median test. A subanalysis was performed by identifying women in the control group with a history of attempting conception without success (subfertile group) and with a spontaneous conception in fewer than 12 months resulting in a live birth (fertile group). Age-specific AFC percentiles were calculated and compared within strata determined by age at the time of attempted conception.

RESULT(S):

AFCs were significantly lower in infertile women than in control women across age groups up to 40 years of age. Average FSH levels were significantly higher in the younger-age infertile group versus the community. AFC percentiles differ significantly between fertile and subfertile women within the community up to 40 years of age.

CONCLUSION(S):

Decreased AFC in infertile women suggests that factors affecting the size of the remaining follicle pool in younger women also affect oocyte quality and the likelihood of conception.

PMID:
21376313
PMCID:
PMC3080442
DOI:
10.1016/j.fertnstert.2011.01.151
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center