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Items: 10


A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.

Dbouk HA, Pang H, Fiser A, Backer JM.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19897-902. doi: 10.1073/pnas.1008739107. Epub 2010 Oct 28.


Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Huang CH, Mandelker D, Gabelli SB, Amzel LM.

Cell Cycle. 2008 May 1;7(9):1151-6. Epub 2008 Feb 27. Review.


Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors.

Katada T, Kurosu H, Okada T, Suzuki T, Tsujimoto N, Takasuga S, Kontani K, Hazeki O, Ui M.

Chem Phys Lipids. 1999 Apr;98(1-2):79-86. Review.


Human tumor mutants in the p110alpha subunit of PI3K.

Liu Z, Roberts TM.

Cell Cycle. 2006 Apr;5(7):675-7. Epub 2006 Apr 1. Review.


Should individual PI3 kinase isoforms be targeted in cancer?

Jia S, Roberts TM, Zhao JJ.

Curr Opin Cell Biol. 2009 Apr;21(2):199-208. doi: 10.1016/ Epub 2009 Feb 4. Review.


A beta version of life: p110β takes center stage.

Dbouk HA, Backer JM.

Oncotarget. 2010 Dec;1(8):729-33. Review.


Phosphatidylinositol 3-kinase: the oncoprotein.

Vogt PK, Hart JR, Gymnopoulos M, Jiang H, Kang S, Bader AG, Zhao L, Denley A.

Curr Top Microbiol Immunol. 2010;347:79-104. doi: 10.1007/82_2010_80. Review.


Targeting the protein-protein interaction between IRS1 and mutant p110α for cancer therapy.

Hao Y, Zhao S, Wang Z.

Toxicol Pathol. 2014 Jan;42(1):140-7. doi: 10.1177/0192623313506794. Epub 2013 Oct 31. Review.


p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?

Singh P, Dar MS, Dar MJ.

FEBS Lett. 2016 Sep;590(18):3071-82. doi: 10.1002/1873-3468.12377. Epub 2016 Sep 12. Review.


The structural basis of PI3K cancer mutations: from mechanism to therapy.

Liu S, Knapp S, Ahmed AA.

Cancer Res. 2014 Feb 1;74(3):641-6. doi: 10.1158/0008-5472.CAN-13-2319. Epub 2014 Jan 23. Review.

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