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Emerg Infect Dis. 2010 Jul;16(7):1063-7. doi: 10.3201/eid1607.091840.

Extensive drug resistance in malaria and tuberculosis.

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  • 1US Agency for International Development, Bangkok 10330, Thailand.


Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria. Recent declines in the clinical effectiveness of antimalarial drugs, including artemisinin-based combination therapy, have prompted the need to revise the definitions of and/or to recategorize antimalarial drug resistance to include extensively drug-resistant malaria. Applying precise case definitions to different levels of drug resistance in malaria and TB is useful for individual patient care and for public health.

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