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Items: 1 to 20 of 29

1.

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.

Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):329-46. doi: 10.1080/10937404.2010.483949.

PMID:
20574906
2.

Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Xu C, Li CY, Kong AN.

Arch Pharm Res. 2005 Mar;28(3):249-68. Review.

PMID:
15832810
3.

Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

Rushmore TH, Kong AN.

Curr Drug Metab. 2002 Oct;3(5):481-90. Review.

PMID:
12369894
4.
5.

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.

Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C.

Chem Biol Interact. 2007 May 20;168(1):66-73. Epub 2006 Dec 16. Review.

PMID:
17241619
6.

Pathophysiological factors affecting CAR gene expression.

Pascussi JM, Dvorák Z, Gerbal-Chaloin S, Assenat E, Maurel P, Vilarem MJ.

Drug Metab Rev. 2003 Nov;35(4):255-68. Review.

PMID:
14705859
7.

Sex-dependent metabolism of xenobiotics.

Mugford CA, Kedderis GL.

Drug Metab Rev. 1998 Aug;30(3):441-98. Review.

PMID:
9710703
8.

A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.

Sonoda J, Rosenfeld JM, Xu L, Evans RM, Xie W.

Curr Drug Metab. 2003 Feb;4(1):59-72. Review.

PMID:
12570746
9.

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

Gómez-Lechón MJ, Donato MT, Castell JV, Jover R.

Curr Drug Metab. 2004 Oct;5(5):443-62. Review.

PMID:
15544436
10.

Human and animal hepatocytes in vitro with extrapolation in vivo.

O'Brien PJ, Chan K, Silber PM.

Chem Biol Interact. 2004 Nov 1;150(1):97-114. Review.

PMID:
15522264
11.
12.

Hepatocytes: the powerhouse of biotransformation.

Sevior DK, Pelkonen O, Ahokas JT.

Int J Biochem Cell Biol. 2012 Feb;44(2):257-61. doi: 10.1016/j.biocel.2011.11.011. Epub 2011 Nov 20. Review.

PMID:
22123318
13.

General review on in vitro hepatocyte models and their applications.

Guguen-Guillouzo C, Guillouzo A.

Methods Mol Biol. 2010;640:1-40. doi: 10.1007/978-1-60761-688-7_1. Review.

PMID:
20645044
14.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

15.

Regulation of hepatic transporters by xenobiotic receptors.

Klaassen CD, Slitt AL.

Curr Drug Metab. 2005 Aug;6(4):309-28. Review.

PMID:
16101571
16.

Optimization of the HepaRG cell model for drug metabolism and toxicity studies.

Anthérieu S, Chesné C, Li R, Guguen-Guillouzo C, Guillouzo A.

Toxicol In Vitro. 2012 Dec;26(8):1278-85. doi: 10.1016/j.tiv.2012.05.008. Epub 2012 May 27. Review.

PMID:
22643240
17.

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

Hewitt NJ, Lechón MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, Hengstler JG.

Drug Metab Rev. 2007;39(1):159-234. Review.

PMID:
17364884
18.

Metabolism of xenobiotics of human environments.

Croom E.

Prog Mol Biol Transl Sci. 2012;112:31-88. doi: 10.1016/B978-0-12-415813-9.00003-9. Review.

PMID:
22974737
19.

Predictive models and computational toxicology.

Knudsen T, Martin M, Chandler K, Kleinstreuer N, Judson R, Sipes N.

Methods Mol Biol. 2013;947:343-74. doi: 10.1007/978-1-62703-131-8_26. Review.

PMID:
23138916
20.

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies.

Fraczek J, Bolleyn J, Vanhaecke T, Rogiers V, Vinken M.

Arch Toxicol. 2013 Apr;87(4):577-610. doi: 10.1007/s00204-012-0983-3. Epub 2012 Dec 15. Review.

PMID:
23242478

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