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Items: 4


Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV.

J Clin Invest. 2009 Nov;119(11):3437-49. doi: 10.1172/JCI38476.


The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol.

Kalmar B, Lu CH, Greensmith L.

Pharmacol Ther. 2014 Jan;141(1):40-54. doi: 10.1016/j.pharmthera.2013.08.003. Review.


Rodent Models of Amyotrophic Lateral Sclerosis.

Philips T, Rothstein JD.

Curr Protoc Pharmacol. 2015 Jun 1;69:5.67.1-21. doi: 10.1002/0471141755.ph0567s69. Review.


Cytoprotective protein C pathways and implications for stroke and neurological disorders.

Zlokovic BV, Griffin JH.

Trends Neurosci. 2011 Apr;34(4):198-209. doi: 10.1016/j.tins.2011.01.005. Review.

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