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Items: 1 to 20 of 46

1.

Non-genetic cell-to-cell variability and the consequences for pharmacology.

Niepel M, Spencer SL, Sorger PK.

Curr Opin Chem Biol. 2009 Dec;13(5-6):556-61. doi: 10.1016/j.cbpa.2009.09.015. Epub 2009 Oct 14. Review.

2.

Noise in gene expression: origins, consequences, and control.

Raser JM, O'Shea EK.

Science. 2005 Sep 23;309(5743):2010-3. Review.

3.

Identifying druggable disease-modifying gene products.

Dixon SJ, Stockwell BR.

Curr Opin Chem Biol. 2009 Dec;13(5-6):549-55. doi: 10.1016/j.cbpa.2009.08.003. Epub 2009 Sep 7. Review.

4.

Stochasticity in gene expression: from theories to phenotypes.

Kaern M, Elston TC, Blake WJ, Collins JJ.

Nat Rev Genet. 2005 Jun;6(6):451-64. Review.

PMID:
15883588
5.

Using gene expression noise to understand gene regulation.

Munsky B, Neuert G, van Oudenaarden A.

Science. 2012 Apr 13;336(6078):183-7. doi: 10.1126/science.1216379. Review.

6.

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.

Wagner BK, Clemons PA.

Curr Opin Chem Biol. 2009 Dec;13(5-6):539-48. doi: 10.1016/j.cbpa.2009.09.018. Epub 2009 Oct 12. Review.

7.

Clinical pharmacology for the primary care physician.

O'Donnell JJ 3rd, O'Donnell JT, Juettner VM.

Dis Mon. 2012 Oct;58(10):558-610. doi: 10.1016/j.disamonth.2012.07.003. Review. No abstract available.

PMID:
22999026
8.

A cellular perspective on conformational disease: the role of genetic background and proteostasis networks.

Gidalevitz T, Kikis EA, Morimoto RI.

Curr Opin Struct Biol. 2010 Feb;20(1):23-32. doi: 10.1016/j.sbi.2009.11.001. Epub 2010 Jan 5. Review.

9.

The role of LKB1 and AMPK in cellular responses to stress and damage.

Alexander A, Walker CL.

FEBS Lett. 2011 Apr 6;585(7):952-7. doi: 10.1016/j.febslet.2011.03.010. Epub 2011 Mar 12. Review.

10.

Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapy.

Lin JH.

Curr Drug Metab. 2007 Feb;8(2):109-36. Review.

PMID:
17305491
11.

Cellular defenses against damage from reactive oxygen species.

Yu BP.

Physiol Rev. 1994 Jan;74(1):139-62. Review. No abstract available. Erratum in: Physiol Rev 1995 Jan;75(1):preceding 1.

PMID:
8295932
12.

Regulation of noise in gene expression.

Sanchez A, Choubey S, Kondev J.

Annu Rev Biophys. 2013;42:469-91. doi: 10.1146/annurev-biophys-083012-130401. Epub 2013 Mar 21. Review.

PMID:
23527780
13.

Preclinical in vitro models from genetically engineered mice for breast and colon cancer (Review).

Telang N, Katdare M.

Oncol Rep. 2011 May;25(5):1195-201. doi: 10.3892/or.2011.1215. Epub 2011 Mar 10. Review.

PMID:
21399881
14.

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.

Loewer A, Lahav G.

Curr Opin Genet Dev. 2011 Dec;21(6):753-8. doi: 10.1016/j.gde.2011.09.010. Epub 2011 Oct 15. Review.

15.

Structural systems pharmacology: the role of 3D structures in next-generation drug development.

Duran-Frigola M, Mosca R, Aloy P.

Chem Biol. 2013 May 23;20(5):674-84. doi: 10.1016/j.chembiol.2013.03.004. Review.

16.

Noise in biological systems: pros, cons, and mechanisms of control.

Pilpel Y.

Methods Mol Biol. 2011;759:407-25. doi: 10.1007/978-1-61779-173-4_23. Review.

PMID:
21863500
17.

[The time structure of the organism. Effects on cellular reactivity and drug susceptibility].

von Mayersbach H.

Arzneimittelforschung. 1978;28(10a):1824-36. Review. German. No abstract available.

PMID:
383088
18.

Potential of a cytomics top-down strategy for drug discovery.

Tárnok A, Pierzchalski A, Valet G.

Curr Med Chem. 2010;17(16):1719-29. Review.

PMID:
20345347
19.

Activation of pharmacologic agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity.

Trush MA, Mimnaugh EG, Gram TE.

Biochem Pharmacol. 1982 Nov 1;31(21):3335-46. Review. No abstract available.

PMID:
6756414
20.

Protein biosensors based on the principle of fluorescence resonance energy transfer for monitoring cellular dynamics.

Li IT, Pham E, Truong K.

Biotechnol Lett. 2006 Dec;28(24):1971-82. Epub 2006 Oct 5. Review.

PMID:
17021660

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