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J Ethnopharmacol. 2009 Dec 10;126(3):447-54. doi: 10.1016/j.jep.2009.09.017. Epub 2009 Sep 19.

Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.

Author information

1
Department of Biotechnology, Konkuk University, 322 Danwol-dong, Chungju 380-701, Republic of Korea.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Chrysanthemum morifolium Ramat (Asteraceae) has (CM) long been used in Korean and Chinese traditional herbal medicines with numerous therapeutic applications.

AIM OF THE STUDY:

To evaluate the neuroprotective activities of Chrysanthemum morifolium (CM) extract against 1-methyl-4-phenylpridinium ions (MPP(+)), Parkinsonian toxin through oxidative stress and impaired energy metabolism, in human SH-SY5Y neuroblastoma cells and the underlying mechanisms.

MATERIALS AND METHODS:

The effects of CM against MPP(+)-induced cytotoxicity and neuronal cell viability, oxidative damage, the expression of Bcl-2 and Bax, caspase-3 and poly(ADP-ribose) polymerase (PARP) proteolysis were evaluated by using SH-SY5Y neuroblastoma cells.

RESULTS:

CM effectively inhibited the cytotoxicity and improved cell viability. CM also attenuated the elevation of reactive oxygen species (ROS) level, increase in Bax/Bcl-2 ratio, cleavage of caspase-3 and PARP proteolysis.

CONCLUSION:

These results demonstrate that CM possesses potent neuroprotective activity and therefore, might be a potential candidate in neurodegenerative diseases such as Parkinson's disease.

PMID:
19770030
DOI:
10.1016/j.jep.2009.09.017
[Indexed for MEDLINE]
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