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Items: 12

1.

Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.

Hodgson RA, Bertorelli R, Varty GB, Lachowicz JE, Forlani A, Fredduzzi S, Cohen-Williams ME, Higgins GA, Impagnatiello F, Nicolussi E, Parra LE, Foster C, Zhai Y, Neustadt BR, Stamford AW, Parker EM, Reggiani A, Hunter JC.

J Pharmacol Exp Ther. 2009 Jul;330(1):294-303. doi: 10.1124/jpet.108.149617. Epub 2009 Mar 30.

3.

Novel investigational adenosine A2A receptor antagonists for Parkinson's disease.

Pinna A.

Expert Opin Investig Drugs. 2009 Nov;18(11):1619-31. doi: 10.1517/13543780903241615. Review.

PMID:
19888872
4.

An update on adenosine A2A receptors as drug target in Parkinson's disease.

Vallano A, Fernandez-Duenas V, Pedros C, Arnau JM, Ciruela F.

CNS Neurol Disord Drug Targets. 2011 Sep 1;10(6):659-69. Review.

PMID:
21838670
5.

Novel therapy in Parkinson's disease: adenosine A(2A) receptor antagonists.

Szabó N, Kincses ZT, Vécsei L.

Expert Opin Drug Metab Toxicol. 2011 Apr;7(4):441-55. doi: 10.1517/17425255.2011.557066. Epub 2011 Feb 19. Review.

PMID:
21332415
6.

7-(2-(4-(2-Fluoro-4-[123I]iodophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine.

Chopra A.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2013 Apr 22 [updated 2013 Jun 27].

7.

Blocking striatal adenosine A2A receptors: a new strategy for basal ganglia disorders.

Müller CE, Ferré S.

Recent Pat CNS Drug Discov. 2007 Jan;2(1):1-21. Review.

PMID:
18221214
9.

Involvement of adenosine A2A receptors in depression and anxiety.

Yamada K, Kobayashi M, Kanda T.

Int Rev Neurobiol. 2014;119:373-93. doi: 10.1016/B978-0-12-801022-8.00015-5. Review.

PMID:
25175973
10.

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists.

Redenti S, Ciancetta A, Pastorin G, Cacciari B, Moro S, Spalluto G, Federico S.

Curr Top Med Chem. 2016;16(28):3224-3257. Review.

PMID:
27150365
11.

Adenosine A(2A) receptor antagonists as Positron Emission Tomography (PET) tracers.

Khanapur S, Waarde Av, Ishiwata K, Leenders KL, Dierckx RA, Elsinga PH.

Curr Med Chem. 2014;21(3):312-28. Review.

PMID:
24059232
12.

Pyrazolo derivatives as potent adenosine receptor antagonists: an overview on the structure-activity relationships.

Cheong SL, Venkatesan G, Paira P, Jothibasu R, Mandel AL, Federico S, Spalluto G, Pastorin G.

Int J Med Chem. 2011;2011:480652. doi: 10.1155/2011/480652. Epub 2011 Mar 7. Review.

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