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Items: 17

1.

Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I.

Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033.

2.

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

Karuppagounder SS, Ratan RR.

J Cereb Blood Flow Metab. 2012 Jul;32(7):1347-61. doi: 10.1038/jcbfm.2012.28. Epub 2012 Mar 14. Review.

3.

HIF-prolyl hydroxylases and cardiovascular diseases.

Sen Banerjee S, Thirunavukkarasu M, Tipu Rishi M, Sanchez JA, Maulik N, Maulik G.

Toxicol Mech Methods. 2012 Jun;22(5):347-58. doi: 10.3109/15376516.2012.673088. Review.

PMID:
22424133
4.

Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities.

Weinreb O, Amit T, Mandel S, Kupershmidt L, Youdim MB.

Antioxid Redox Signal. 2010 Sep 15;13(6):919-49. doi: 10.1089/ars.2009.2929. Review.

PMID:
20095867
5.

Cellular oxygen sensing need in CNS function: physiological and pathological implications.

Acker T, Acker H.

J Exp Biol. 2004 Aug;207(Pt 18):3171-88. Review.

6.
7.

Oxygen-sensing under the influence of nitric oxide.

Berchner-Pfannschmidt U, Tug S, Kirsch M, Fandrey J.

Cell Signal. 2010 Mar;22(3):349-56. doi: 10.1016/j.cellsig.2009.10.004. Review.

PMID:
19861159
8.

Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.

Speer R, Ratan RR.

Adv Exp Med Biol. 2016;903:221-43. doi: 10.1007/978-1-4899-7678-9_16. Review.

PMID:
27343100
9.
10.

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

Ratan RR, Siddiq A, Aminova L, Lange PS, Langley B, Ayoub I, Gensert J, Chavez J.

Stroke. 2004 Nov;35(11 Suppl 1):2687-9. Epub 2004 Oct 7. Review.

11.

Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases.

Karuppagounder SS, Kumar A, Shao DS, Zille M, Bourassa MW, Caulfield JT, Alim I, Ratan RR.

Brain Res. 2015 Dec 2;1628(Pt B):273-287. doi: 10.1016/j.brainres.2015.07.030. Epub 2015 Jul 29. Review.

12.

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR.

Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Review.

13.

Hypoxia-inducible factor signalling mechanisms in the central nervous system.

Corcoran A, O'Connor JJ.

Acta Physiol (Oxf). 2013 Aug;208(4):298-310. doi: 10.1111/apha.12117. Epub 2013 Jun 14. Review.

PMID:
23692777
14.

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron.

Bailey PSJ, Nathan JA.

Biomedicines. 2018 May 17;6(2). pii: E60. doi: 10.3390/biomedicines6020060. Review.

15.

Adaptive response to hypoxia and remote ischaemia pre-conditioning: a new hypoxia-inducible factors era in clinical medicine.

Heyman SN, Leibowitz D, Mor-Yosef Levi I, Liberman A, Eisenkraft A, Alcalai R, Khamaisi M, Rosenberger C.

Acta Physiol (Oxf). 2016 Apr;216(4):395-406. doi: 10.1111/apha.12613. Epub 2015 Nov 2. Review.

PMID:
26449466
16.

Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway.

Theriault JR, Perez J, Gilbert S, Palmer M, Schreiber SL, Lindsley CW, Dawson ES, Engers JL, Felts AS, Bates BS, Emmitte KA.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 31 [updated 2013 Mar 14].

17.

HIF Activation Against CVD in CKD: Novel Treatment Opportunities.

Tanaka T, Eckardt KU.

Semin Nephrol. 2018 May;38(3):267-276. doi: 10.1016/j.semnephrol.2018.02.006. Review.

PMID:
29753402

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