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Items: 1 to 20 of 30

1.

Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

Bamborough P, Drewry D, Harper G, Smith GK, Schneider K.

J Med Chem. 2008 Dec 25;51(24):7898-914. doi: 10.1021/jm8011036.

PMID:
19035792
2.

Peptide inhibitors targeting protein kinases.

Eldar-Finkelman H, Eisenstein M.

Curr Pharm Des. 2009;15(21):2463-70. Review.

PMID:
19601843
3.

Design strategies for protein kinase inhibitors.

Parang K, Sun G.

Curr Opin Drug Discov Devel. 2004 Sep;7(5):617-29. Review.

PMID:
15503864
4.

Structural biology contributions to tyrosine kinase drug discovery.

Cowan-Jacob SW, Möbitz H, Fabbro D.

Curr Opin Cell Biol. 2009 Apr;21(2):280-7. doi: 10.1016/j.ceb.2009.01.012. Epub 2009 Feb 7. Review.

PMID:
19208462
5.

The Pim kinases: new targets for drug development.

Swords R, Kelly K, Carew J, Nawrocki S, Mahalingam D, Sarantopoulos J, Bearss D, Giles F.

Curr Drug Targets. 2011 Dec;12(14):2059-66. Review.

PMID:
21777193
6.

Chemical kinomics: a powerful strategy for target deconvolution.

Kim DH, Sim T.

BMB Rep. 2010 Nov;43(11):711-9. doi: 10.5483/BMBRep.2010.43.11.711. Review.

7.

The role of structure in kinase-targeted inhibitor design.

Pratt DJ, Endicott JA, Noble ME.

Curr Opin Drug Discov Devel. 2004 Jul;7(4):428-36. Review.

PMID:
15338952
8.

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.

Anizon F, Shtil AA, Danilenko VN, Moreau P.

Curr Med Chem. 2010;17(34):4114-33. Review.

PMID:
20939820
9.

Targeting cancer with small-molecular-weight kinase inhibitors.

Fabbro D, Cowan-Jacob SW, Möbitz H, Martiny-Baron G.

Methods Mol Biol. 2012;795:1-34. doi: 10.1007/978-1-61779-337-0_1. Review.

PMID:
21960212
10.

Protein kinase biochemistry and drug discovery.

Schwartz PA, Murray BW.

Bioorg Chem. 2011 Dec;39(5-6):192-210. doi: 10.1016/j.bioorg.2011.07.004. Epub 2011 Aug 3. Review.

PMID:
21872901
11.

High-throughput structural biology in drug discovery: protein kinases.

Stout TJ, Foster PG, Matthews DJ.

Curr Pharm Des. 2004;10(10):1069-82. Review.

PMID:
15078142
12.

Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors.

Akritopoulou-Zanze I, Hajduk PJ.

Drug Discov Today. 2009 Mar;14(5-6):291-7. doi: 10.1016/j.drudis.2008.12.002. Epub 2009 Jan 21. Review.

PMID:
19121409
13.

High-throughput kinase profiling as a platform for drug discovery.

Goldstein DM, Gray NS, Zarrinkar PP.

Nat Rev Drug Discov. 2008 May;7(5):391-7. doi: 10.1038/nrd2541. Review.

PMID:
18404149
14.

Kinomics: characterizing the therapeutically validated kinase space.

Vieth M, Sutherland JJ, Robertson DH, Campbell RM.

Drug Discov Today. 2005 Jun 15;10(12):839-46. Review.

PMID:
15970266
15.

Fragment-based approaches to the discovery of kinase inhibitors.

Mortenson PN, Berdini V, O'Reilly M.

Methods Enzymol. 2014;548:69-92. doi: 10.1016/B978-0-12-397918-6.00003-3. Review.

PMID:
25399642
16.

Drug discovery and the human kinome: recent trends.

Eglen R, Reisine T.

Pharmacol Ther. 2011 May;130(2):144-56. doi: 10.1016/j.pharmthera.2011.01.007. Epub 2011 Jan 20. Review.

PMID:
21256157
17.

Insights from Pim1 structure for anti-cancer drug design.

Ogawa N, Yuki H, Tanaka A.

Expert Opin Drug Discov. 2012 Dec;7(12):1177-92. doi: 10.1517/17460441.2012.727394. Epub 2012 Sep 25. Review.

PMID:
23004574
18.

Extending kinome coverage by analysis of kinase inhibitor broad profiling data.

Jacoby E, Tresadern G, Bembenek S, Wroblowski B, Buyck C, Neefs JM, Rassokhin D, Poncelet A, Hunt J, van Vlijmen H.

Drug Discov Today. 2015 Jun;20(6):652-8. doi: 10.1016/j.drudis.2015.01.002. Epub 2015 Jan 14. Review.

PMID:
25596550
19.

The pharmaceutical biochemistry group: where pharmaceutical chemistry meets biology and drug delivery.

Kalia YN, Perozzo R, Scapozza L.

Chimia (Aarau). 2012;66(5):313-9. doi: 10.2533/chimia.2012.313. Review.

PMID:
22867543
20.

System-based drug discovery within the human kinome.

Bamborough P.

Expert Opin Drug Discov. 2012 Nov;7(11):1053-70. doi: 10.1517/17460441.2012.724056. Epub 2012 Sep 13. Review.

PMID:
22971083

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