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Childs Nerv Syst. 2008 Jul;24(7):807-13. doi: 10.1007/s00381-007-0576-2. Epub 2008 Feb 22.

Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy.

Author information

1
Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Abstract

OBJECTIVE:

The study objective was to detect abnormalities and identify relationships between brain metabolic ratios determined by proton magnetic resonance spectroscopic imaging ((1)H-MRSI) and neuropsychological (NP) function in cancer patients at risk for neurotoxicity.

METHODS:

Thirty-two patients received (1)H-MRSI using a multi-slice, multi-voxel technique on a 1.5T magnet. Cho/NAA, NAA/Cr, and Cho/Cr ratios were identified in seven pre-determined sites without tumor involvement. A battery of age-appropriate NP tests was administered within 7 days of imaging. Relationships were examined between test scores and metabolite ratios.

CONCLUSIONS:

This study identifies relationships between brain metabolite ratios and cognitive functioning in cancer patients. (1)H-MRSI may be useful in early detection of neurotoxic effects, but prospective longitudinal studies in a homogeneous population are recommended to determine the prognostic value.

PMID:
18293002
PMCID:
PMC2398763
DOI:
10.1007/s00381-007-0576-2
[Indexed for MEDLINE]
Free PMC Article

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