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Am J Cardiol. 2006 Mar 1;97(5):655-8. Epub 2006 Jan 9.

Meta-analysis of the effect of thiazolidinediones on serum C-reactive protein levels.

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  • 1Prudich Medical Center, Montcalm, West Virginia. rqayyum@hotmail.com

Abstract

We conducted a meta-analysis of randomized clinical trials to evaluate the effect of thiazolidinediones on serum C-reactive protein levels. Compared with placebo, treatment with thiazolidinediones significantly decreased the serum C-reactive protein levels (mean -0.82 mg/L, 95% confidence interval -1.15 to -0.49 mg/L, p <0.0001). In a subgroup analysis, the effect of thiazolidinediones on the serum C-reactive protein levels was more pronounced in diabetic patients (mean -1.24 mg/L, 95% confidence interval -2.15 to -0.32 mg/L, p = 0.008) compared with nondiabetic patients (mean -0.27 mg/L, 95% confidence interval -0.41 to -0.14 mg/L, p <0.0001).

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