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Randomized trials stopped early for benefit: a systematic review.

Montori VM, Devereaux PJ, Adhikari NK, Burns KE, Eggert CH, Briel M, Lacchetti C, Leung TW, Darling E, Bryant DM, Bucher HC, Schünemann HJ, Meade MO, Cook DJ, Erwin PJ, Sood A, Sood R, Lo B, Thompson CA, Zhou Q, Mills E, Guyatt GH.

JAMA. 2005 Nov 2;294(17):2203-9. Review.


Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.

Bassler D, Briel M, Montori VM, Lane M, Glasziou P, Zhou Q, Heels-Ansdell D, Walter SD, Guyatt GH; STOPIT-2 Study Group, Flynn DN, Elamin MB, Murad MH, Abu Elnour NO, Lampropulos JF, Sood A, Mullan RJ, Erwin PJ, Bankhead CR, Perera R, Ruiz Culebro C, You JJ, Mulla SM, Kaur J, Nerenberg KA, Schünemann H, Cook DJ, Lutz K, Ribic CM, Vale N, Malaga G, Akl EA, Ferreira-Gonzalez I, Alonso-Coello P, Urrutia G, Kunz R, Bucher HC, Nordmann AJ, Raatz H, da Silva SA, Tuche F, Strahm B, Djulbegovic B, Adhikari NK, Mills EJ, Gwadry-Sridhar F, Kirpalani H, Soares HP, Karanicolas PJ, Burns KE, Vandvik PO, Coto-Yglesias F, Chrispim PP, Ramsay T.

JAMA. 2010 Mar 24;303(12):1180-7. doi: 10.1001/jama.2010.310. Review.


Randomized trials stopped early for harm in HIV/AIDS: a systematic survey.

Mills E, Cooper C, Wu P, Rachlis B, Singh S, Guyatt GH.

HIV Clin Trials. 2006 Jan-Feb;7(1):24-33. Review.


An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules.

Stegert M, Kasenda B, von Elm E, You JJ, Blümle A, Tomonaga Y, Saccilotto R, Amstutz A, Bengough T, Briel M; DISCO study group.

J Clin Epidemiol. 2016 Jan;69:152-60. doi: 10.1016/j.jclinepi.2015.05.023. Epub 2015 Jun 4. Review.


Issues in data monitoring and interim analysis of trials.

Grant AM, Altman DG, Babiker AB, Campbell MK, Clemens FJ, Darbyshire JH, Elbourne DR, McLeer SK, Parmar MK, Pocock SJ, Spiegelhalter DJ, Sydes MR, Walker AE, Wallace SA; DAMOCLES study group.

Health Technol Assess. 2005 Mar;9(7):1-238, iii-iv. Review.


A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.

Fernandes RM, van der Lee JH, Offringa M.

BMC Pediatr. 2009 Dec 13;9:77. doi: 10.1186/1471-2431-9-77. Review.


Antioxidants for male subfertility.

Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ.

Cochrane Database Syst Rev. 2014;(12):CD007411. doi: 10.1002/14651858.CD007411.pub3. Epub 2014 Dec 15. Review.


A rapid and systematic review of the clinical effectiveness and cost-effectiveness of topotecan for ovarian cancer.

Forbes C, Shirran L, Bagnall AM, Duffy S, ter Riet G.

Health Technol Assess. 2001;5(28):1-110. Review.


Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit.

Murad MH, Guyatt GH, Domecq JP, Vernooij RWM, Erwin PJ, Meerpohl JJ, Prutsky GJ, Akl EA, Mueller K, Bassler D, Schandelmaier S, Walter SD, Busse JW, Kasenda B, Pagano G, Pardo-Hernandez H, Montori VM, Wang Z, Briel M.

J Clin Epidemiol. 2017 Feb;82:12-19. doi: 10.1016/j.jclinepi.2016.10.006. Epub 2016 Nov 8. Review.


Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials.

Anglemyer A, Horvath HT, Bero L.

Cochrane Database Syst Rev. 2014 Apr 29;(4):MR000034. doi: 10.1002/14651858.MR000034.pub2. Review.


Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design.

Prutsky GJ, Domecq JP, Erwin PJ, Briel M, Montori VM, Akl EA, Meerpohl JJ, Bassler D, Schandelmaier S, Walter SD, Zhou Q, Coello PA, Moja L, Walter M, Thorlund K, Glasziou P, Kunz R, Ferreira-Gonzalez I, Busse J, Sun X, Kristiansen A, Kasenda B, Qasim-Agha O, Pagano G, Pardo-Hernandez H, Urrutia G, Murad MH, Guyatt G.

Trials. 2013 Oct 16;14:335. doi: 10.1186/1745-6215-14-335. Review.


The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation.

Picot J, Jones J, Colquitt JL, Gospodarevskaya E, Loveman E, Baxter L, Clegg AJ.

Health Technol Assess. 2009 Sep;13(41):1-190, 215-357, iii-iv. doi: 10.3310/hta13410. Review.


Systematic reviews of the effectiveness of day care for people with severe mental disorders: (1) acute day hospital versus admission; (2) vocational rehabilitation; (3) day hospital versus outpatient care.

Marshall M, Crowther R, Almaraz-Serrano A, Creed F, Sledge W, Kluiter H, Roberts C, Hill E, Wiersma D, Bond GR, Huxley P, Tyrer P.

Health Technol Assess. 2001;5(21):1-75. Review.


Male circumcision for prevention of heterosexual acquisition of HIV in men.

Siegfried N, Muller M, Deeks JJ, Volmink J.

Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003362. doi: 10.1002/14651858.CD003362.pub2. Review.


Interventions for treating proximal humeral fractures in adults.

Handoll HH, Brorson S.

Cochrane Database Syst Rev. 2015 Nov 11;(11):CD000434. doi: 10.1002/14651858.CD000434.pub4. Review.


Screening for prostate cancer.

Ilic D, Neuberger MM, Djulbegovic M, Dahm P.

Cochrane Database Syst Rev. 2013 Jan 31;(1):CD004720. doi: 10.1002/14651858.CD004720.pub3. Review.


Exercise-based cardiac rehabilitation for coronary heart disease.

Anderson L, Thompson DR, Oldridge N, Zwisler AD, Rees K, Martin N, Taylor RS.

Cochrane Database Syst Rev. 2016 Jan 5;(1):CD001800. doi: 10.1002/14651858.CD001800.pub3. Review.


Antidepressants for the treatment of depression in people with cancer.

Ostuzzi G, Matcham F, Dauchy S, Barbui C, Hotopf M.

Cochrane Database Syst Rev. 2015 Jun 1;(6):CD011006. doi: 10.1002/14651858.CD011006.pub2. Review.


Comparison of cellulose, modified cellulose and synthetic membranes in the haemodialysis of patients with end-stage renal disease.

MacLeod A, Daly C, Khan I, Vale L, Campbell M, Wallace S, Cody J, Donaldson C, Grant A.

Cochrane Database Syst Rev. 2001;(3):CD003234. Review. Update in: Cochrane Database Syst Rev. 2005;(3):CD003234.


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