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Items: 8

1.

A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.

Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE.

J Biol Chem. 2005 Jul 22;280(29):27329-38. Epub 2005 May 27.

2.

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, Saito N.

Pharmacol Ther. 2002 Feb-Mar;93(2-3):271-81. Review.

PMID:
12191619
3.
4.

Protein kinase C delta (PKC delta): activation mechanisms and functions.

Kikkawa U, Matsuzaki H, Yamamoto T.

J Biochem. 2002 Dec;132(6):831-9. Review.

5.

C1 domains exposed: from diacylglycerol binding to protein-protein interactions.

Colón-González F, Kazanietz MG.

Biochim Biophys Acta. 2006 Aug;1761(8):827-37. Epub 2006 May 13. Review.

PMID:
16861033
6.
7.

Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.

Irie K, Nakagawa Y, Ohigashi H.

Chem Rec. 2005;5(4):185-95. Review.

PMID:
16041745
8.

Wealth of opportunity - the C1 domain as a target for drug development.

Blumberg PM, Kedei N, Lewin NE, Yang D, Czifra G, Pu Y, Peach ML, Marquez VE.

Curr Drug Targets. 2008 Aug;9(8):641-52. Review.

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