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Items: 1 to 20 of 42

1.

Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses.

Wyde ME, Kirwan SE, Zhang F, Laughter A, Hoffman HB, Bartolucci-Page E, Gaido KW, Yan B, You L.

Toxicol Sci. 2005 Aug;86(2):281-90. Epub 2005 May 18.

PMID:
15901914
2.

Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Xu C, Li CY, Kong AN.

Arch Pharm Res. 2005 Mar;28(3):249-68. Review.

PMID:
15832810
3.

Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

Rushmore TH, Kong AN.

Curr Drug Metab. 2002 Oct;3(5):481-90. Review.

PMID:
12369894
4.
5.

Xenosensors CAR and PXR at work: impact on statin metabolism.

Marino M, di Masi A, Trezza V, Pallottini V, Polticelli F, Ascenzi P.

Curr Drug Metab. 2011 Mar;12(3):300-11. Review.

PMID:
21395534
6.

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.

Chai X, Zeng S, Xie W.

Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):253-66. doi: 10.1517/17425255.2013.754010. Epub 2013 Jan 17. Review.

PMID:
23327618
7.

CAR and PXR: xenosensors of endocrine disrupters?

Kretschmer XC, Baldwin WS.

Chem Biol Interact. 2005 Aug 15;155(3):111-28. Review.

PMID:
16054614
8.

Xenobiotic-sensing nuclear receptors CAR and PXR as drug targets in cholestatic liver disease.

Kakizaki S, Takizawa D, Tojima H, Yamazaki Y, Mori M.

Curr Drug Targets. 2009 Nov;10(11):1156-1163. Review.

PMID:
19925451
9.

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.

Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG.

Crit Rev Toxicol. 2014 Jan;44(1):64-82. doi: 10.3109/10408444.2013.835786. Epub 2013 Nov 4. Review.

10.

Current in vitro high throughput screening approaches to assess nuclear receptor activation.

Raucy JL, Lasker JM.

Curr Drug Metab. 2010 Nov;11(9):806-14. Review.

PMID:
21189134
11.

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

Handschin C, Meyer UA.

Arch Biochem Biophys. 2005 Jan 15;433(2):387-96. Review.

PMID:
15581595
12.

Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome p450 enzymes.

Brtko J, Dvorak Z.

Curr Drug Metab. 2011 Feb;12(2):71-88. Review.

PMID:
21401514
13.

Targeting xenobiotic receptors PXR and CAR for metabolic diseases.

Gao J, Xie W.

Trends Pharmacol Sci. 2012 Oct;33(10):552-8. doi: 10.1016/j.tips.2012.07.003. Epub 2012 Aug 10. Review.

14.

CAR and PXR: the xenobiotic-sensing receptors.

Timsit YE, Negishi M.

Steroids. 2007 Mar;72(3):231-46. Epub 2006 Dec 20. Review.

15.

3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR.

Wu B, Li S, Dong D.

Drug Discov Today. 2013 Jun;18(11-12):574-81. doi: 10.1016/j.drudis.2013.01.001. Epub 2013 Jan 5. Review.

PMID:
23299080
16.

Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism.

Gao J, Xie W.

Drug Metab Dispos. 2010 Dec;38(12):2091-5. doi: 10.1124/dmd.110.035568. Epub 2010 Aug 24. Review.

17.
18.

Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.

Oladimeji P, Cui H, Zhang C, Chen T.

Expert Opin Drug Metab Toxicol. 2016 Sep;12(9):997-1010. doi: 10.1080/17425255.2016.1201069. Epub 2016 Jun 23. Review.

PMID:
27295009
19.

PXR- and CAR-mediated herbal effect on human diseases.

Xu C, Huang M, Bi H.

Biochim Biophys Acta. 2016 Sep;1859(9):1121-9. doi: 10.1016/j.bbagrm.2016.02.009. Epub 2016 Feb 22. Review.

PMID:
26906544
20.

Roles of xenobiotic receptors in vascular pathophysiology.

Xiao L, Zhang Z, Luo X.

Circ J. 2014;78(7):1520-30. Epub 2014 May 26. Review.

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