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Opt Lett. 2003 Sep 15;28(18):1701-3.

Noncontact optical tomography of turbid media.

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  • 1Laboratory for Bio-optics and Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital & Harvard Medical School, Building 149, 13th Street, Suite 5209, Charlestown, Massachusetts 02129, USA.


Optical tomography of turbid media has so far been limited by systems that require fixed geometries or measurements employing fibers. We present a system that records noncontact optical measurements from diffuse media of arbitrary shapes and retrieves the three-dimensional surface information of the diffuse medium. We further present a novel method of combining this composite data set and obtain accurate fluorescence reconstructions. This approach offers significant experimental simplicity and yields high-information-content datasets. The performance of this novel tomographic approach is demonstrated with experimental reconstructions of phantoms.

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