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Items: 1 to 20 of 34

1.

Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.

Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.

J Biol Chem. 2003 Jul 25;278(30):27612-9. Epub 2003 May 15.

2.

Polyamine metabolism in Leishmania: from arginine to trypanothione.

Colotti G, Ilari A.

Amino Acids. 2011 Feb;40(2):269-85. doi: 10.1007/s00726-010-0630-3. Epub 2010 May 29. Review.

PMID:
20512387
3.

Metabolism and functions of trypanothione in the Kinetoplastida.

Fairlamb AH, Cerami A.

Annu Rev Microbiol. 1992;46:695-729. Review.

PMID:
1444271
4.

Thiol metabolism of the trypanosomatids as potential drug targets.

Steenkamp DJ.

IUBMB Life. 2002 Apr-May;53(4-5):243-8. Review.

5.

The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

Krauth-Siegel RL, Meiering SK, Schmidt H.

Biol Chem. 2003 Apr;384(4):539-49. Review.

PMID:
12751784
6.

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.

Augustyns K, Amssoms K, Yamani A, Rajan PK, Haemers A.

Curr Pharm Des. 2001 Aug;7(12):1117-41. Review.

PMID:
11472257
7.

Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.

Irigoín F, Cibils L, Comini MA, Wilkinson SR, Flohé L, Radi R.

Free Radic Biol Med. 2008 Sep 15;45(6):733-42. doi: 10.1016/j.freeradbiomed.2008.05.028. Epub 2008 Jun 12. Review.

PMID:
18588970
8.

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.

Krauth-Siegel RL, Comini MA.

Biochim Biophys Acta. 2008 Nov;1780(11):1236-48. doi: 10.1016/j.bbagen.2008.03.006. Epub 2008 Mar 18. Review.

PMID:
18395526
9.

Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids.

Manta B, Comini M, Medeiros A, Hugo M, Trujillo M, Radi R.

Biochim Biophys Acta. 2013 May;1830(5):3199-216. doi: 10.1016/j.bbagen.2013.01.013. Epub 2013 Feb 8. Review.

PMID:
23396001
10.

The trypanothione system.

Krauth-Siegel LR, Comini MA, Schlecker T.

Subcell Biochem. 2007;44:231-51. Review.

PMID:
18084897
11.
12.

Targeting trypanothione metabolism in trypanosomatid human parasites.

Olin-Sandoval V, Moreno-Sánchez R, Saavedra E.

Curr Drug Targets. 2010 Dec;11(12):1614-30. Review.

PMID:
20735352
13.

Interconversion, catabolism and elimination of the polyamines.

Seiler N, Bolkenius FN, Rennert OM.

Med Biol. 1981 Dec;59(5-6):334-46. Review.

PMID:
7040832
14.

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.

Comini MA, Krauth-Siegel RL, Bellanda M.

Antioxid Redox Signal. 2013 Sep 1;19(7):708-22. doi: 10.1089/ars.2012.4932. Epub 2012 Oct 25. Review.

15.

Polyamine-trypanothione pathway: an update.

Ilari A, Fiorillo A, Genovese I, Colotti G.

Future Med Chem. 2017 Jan;9(1):61-77. doi: 10.4155/fmc-2016-0180. Epub 2016 Dec 13. Review.

PMID:
27957878
16.

Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development.

Schmidt A, Krauth-Siegel RL.

Curr Top Med Chem. 2002 Nov;2(11):1239-59. Review.

PMID:
12171583
17.

Thiol-based redox metabolism of protozoan parasites.

Müller S, Liebau E, Walter RD, Krauth-Siegel RL.

Trends Parasitol. 2003 Jul;19(7):320-8. Review.

PMID:
12855383
18.

Investigation of polyamine metabolism by high-performance liquid chromatographic and gas chromatographic profiling methods.

Muskiet FA, Dorhout B, van den Berg GA, Hessels J.

J Chromatogr B Biomed Appl. 1995 May 19;667(2):189-98. Review.

PMID:
7663691
19.

The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases.

Flohé L.

Biotechnol Adv. 2012 Jan-Feb;30(1):294-301. doi: 10.1016/j.biotechadv.2011.05.012. Epub 2011 May 19. Review.

PMID:
21620942
20.

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia.

Krauth-Siegel RL, Bauer H, Schirmer RH.

Angew Chem Int Ed Engl. 2005 Jan 21;44(5):690-715. Review.

PMID:
15657967

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