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Items: 13

1.

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.

Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. Epub 2001 Oct 23. Erratum in: Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15393.

2.

Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.

Johnson MP, Nisenbaum ES, Large TH, Emkey R, Baez M, Kingston AE.

Biochem Soc Trans. 2004 Nov;32(Pt 5):881-7. Review.

PMID:
15494040
3.
4.
5.

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.

Pin JP, Acher F.

Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317. Review.

PMID:
12769621
6.

Ionotropic and metabotropic glutamate receptor structure and pharmacology.

Kew JN, Kemp JA.

Psychopharmacology (Berl). 2005 Apr;179(1):4-29. Epub 2005 Feb 25. Review. Erratum in: Psychopharmacology (Berl). 2005 Oct;182(2):320.

PMID:
15731895
7.

Metabotropic glutamate mGlu1 receptor stimulation and blockade: therapeutic opportunities in psychiatric illness.

Lesage A, Steckler T.

Eur J Pharmacol. 2010 Aug 10;639(1-3):2-16. doi: 10.1016/j.ejphar.2009.12.043. Epub 2010 Apr 2. Review.

PMID:
20371230
8.

Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia.

Fraley ME.

Expert Opin Ther Pat. 2009 Sep;19(9):1259-75. doi: 10.1517/13543770903045009. Review.

PMID:
19552508
9.

Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).

Williams DL Jr, Lindsley CW.

Curr Top Med Chem. 2005;5(9):825-46. Review.

PMID:
16178729
10.

Recent patents on positive allosteric modulators of the metabotropic glutamate 5 receptor as a potential treatment for schizophrenia.

Kanuma K, Aoki T, Shimazaki Y.

Recent Pat CNS Drug Discov. 2010 Jan;5(1):23-34. Review.

PMID:
19832691
11.

Structures of mGluRs shed light on the challenges of drug development of allosteric modulators.

Bennett KA, Doré AS, Christopher JA, Weiss DR, Marshall FH.

Curr Opin Pharmacol. 2015 Feb;20:1-7. doi: 10.1016/j.coph.2014.09.022. Epub 2014 Oct 17. Review.

PMID:
25462286
12.

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ.

Chem Rev. 2016 Jun 8;116(11):6707-41. doi: 10.1021/acs.chemrev.5b00656. Epub 2016 Feb 16. Review.

PMID:
26882314
13.

Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors.

Gasparini F, Floersheim P, Flor PJ, Heinrich M, Inderbitzin W, Ott D, Pagano A, Stierlin C, Stoehr N, Vranesic I, Kuhn R.

Farmaco. 2001 Jan-Feb;56(1-2):95-9. Review.

PMID:
11347975

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