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Items: 1 to 20 of 64

1.

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

Altafaj X, Dierssen M, Baamonde C, Martí E, Visa J, Guimerà J, Oset M, González JR, Flórez J, Fillat C, Estivill X.

Hum Mol Genet. 2001 Sep 1;10(18):1915-23.

PMID:
11555628
2.
3.

Function and regulation of Dyrk1A: towards understanding Down syndrome.

Park J, Song WJ, Chung KC.

Cell Mol Life Sci. 2009 Oct;66(20):3235-40. doi: 10.1007/s00018-009-0123-2. Epub 2009 Aug 14. Review.

PMID:
19685005
4.

On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models.

Galdzicki Z, Siarey R, Pearce R, Stoll J, Rapoport SI.

Brain Res Brain Res Rev. 2001 Apr;35(2):115-45. Review.

PMID:
11336779
5.

The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications.

Hämmerle B, Elizalde C, Galceran J, Becker W, Tejedor FJ.

J Neural Transm Suppl. 2003;(67):129-37. Review.

PMID:
15068245
6.

Understanding mental retardation in Down's syndrome using trisomy 16 mouse models.

Galdzicki Z, Siarey RJ.

Genes Brain Behav. 2003 Jun;2(3):167-78. Review.

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9.

DYRK1A: a potential drug target for multiple Down syndrome neuropathologies.

Becker W, Soppa U, Tejedor FJ.

CNS Neurol Disord Drug Targets. 2014 Feb;13(1):26-33. Review.

PMID:
24152332
10.

Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms.

Rachidi M, Lopes C.

Neurosci Res. 2007 Dec;59(4):349-69. Epub 2007 Aug 15. Review.

PMID:
17897742
11.

Murine models for Down syndrome.

Dierssen M, Fillat C, Crnic L, Arbonés M, Flórez J, Estivill X.

Physiol Behav. 2001 Aug;73(5):859-71. Review.

PMID:
11566219
12.
13.

The cholinergic system in Down's syndrome.

Fodale V, Mafrica F, Caminiti V, Grasso G.

J Intellect Disabil. 2006 Sep;10(3):261-74. Review.

PMID:
16916850
14.

The MNB/DYRK1A protein kinase: genetic and biochemical properties.

Galceran J, de Graaf K, Tejedor FJ, Becker W.

J Neural Transm Suppl. 2003;(67):139-48. Review.

PMID:
15068246
15.

Neuronal cell death in Down's syndrome.

Sawa A.

J Neural Transm Suppl. 1999;57:87-97. Review.

PMID:
10666670
17.

Molecular and cellular mechanisms elucidating neurocognitive basis of functional impairments associated with intellectual disability in Down syndrome.

Rachidi M, Lopes C.

Am J Intellect Dev Disabil. 2010 Mar;115(2):83-112. doi: 10.1352/1944-7558-115.2.83. Review.

PMID:
20441388
18.

Alterations of brain circuits in Down syndrome murine models.

Gotti S, Caricati E, Panzica G.

J Chem Neuroanat. 2011 Dec;42(4):317-26. doi: 10.1016/j.jchemneu.2011.09.002. Epub 2011 Sep 16. Review.

PMID:
21946025
19.

Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.

Becker W, Joost HG.

Prog Nucleic Acid Res Mol Biol. 1999;62:1-17. Review.

PMID:
9932450
20.

Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice.

Smith DJ, Rubin EM.

Hum Mol Genet. 1997;6(10):1729-33. Review.

PMID:
9300665

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