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Items: 1 to 20 of 25

1.

Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.

Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R, Kalwinsky D, Keller F, Khatib Z, Margolin J, Murray J, Quinn J, Ravindranath Y, Ritchey K, Roberts W, Rogers ZR, Schiff D, Steuber C, Tucci F, Kornegay N, Krynetski EY, Relling MV.

J Clin Oncol. 2001 Apr 15;19(8):2293-301.

PMID:
11304783
2.

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.

McLeod HL, Krynetski EY, Relling MV, Evans WE.

Leukemia. 2000 Apr;14(4):567-72. Review.

PMID:
10764140
3.

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

Sanderson J, Ansari A, Marinaki T, Duley J.

Ann Clin Biochem. 2004 Jul;41(Pt 4):294-302. Review.

PMID:
15298741
4.

[Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease].

Gisbert JP, González-Lama Y, Maté J.

Gastroenterol Hepatol. 2006 Nov;29(9):568-83. Review. Spanish.

PMID:
17129552
5.

Clinical pharmacogenomics of thiopurine S-methyltransferase.

Zhou S.

Curr Clin Pharmacol. 2006 Jan;1(1):119-28. Review.

PMID:
18666383
6.

Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.

Gearry RB, Barclay ML.

J Gastroenterol Hepatol. 2005 Aug;20(8):1149-57. Review.

PMID:
16048561
7.

Clinical pharmacology and pharmacogenetics of thiopurines.

Sahasranaman S, Howard D, Roy S.

Eur J Clin Pharmacol. 2008 Aug;64(8):753-67. doi: 10.1007/s00228-008-0478-6. Epub 2008 May 28. Review.

PMID:
18506437
8.

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.

McLeod HL, Siva C.

Pharmacogenomics. 2002 Jan;3(1):89-98. Review.

PMID:
11966406
9.

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.

Krynetski EY, Tai HL, Yates CR, Fessing MY, Loennechen T, Schuetz JD, Relling MV, Evans WE.

Pharmacogenetics. 1996 Aug;6(4):279-90. Review.

PMID:
8873214
10.

Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.

Karas-Kuzelicki N, Mlinaric-Rascan I.

Pharmacogenomics. 2009 Aug;10(8):1309-22. doi: 10.2217/pgs.09.78. Review.

PMID:
19663675
11.

Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.

Booth RA, Ansari MT, Tricco AC, Loit E, Weeks L, Doucette S, Skidmore B, Hoch JS, Tsouros S, Sears M, Sy R, Karsh J, Mani S, Galipeau J, Yurkiewich A, Daniel R, Tsertsvadze A, Yazdi F.

Evid Rep Technol Assess (Full Rep). 2010 Dec;(196):1-282. Review.

12.

Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.

Clunie GP, Lennard L.

Rheumatology (Oxford). 2004 Jan;43(1):13-8. Epub 2003 Oct 17. Review.

PMID:
14566029
13.

The thiopurines: an update.

Coulthard S, Hogarth L.

Invest New Drugs. 2005 Dec;23(6):523-32. Review.

PMID:
16267626
14.

TPMT Polymorphism: When Shield Becomes Weakness.

Katara P, Kuntal H.

Interdiscip Sci. 2016 Jun;8(2):150-5. doi: 10.1007/s12539-015-0111-1. Epub 2015 Aug 22. Review.

PMID:
26297310
15.

Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia.

Azimi F, Jafariyan M, Khatami S, Mortazavi Y, Azad M.

Iran J Ped Hematol Oncol. 2014;4(1):32-8. Epub 2014 Apr 20. Review.

16.

Mercaptopurine Therapy and TPMT Genotype.

Dean L.

In: Pratt V, McLeod H, Dean L, Malheiro A, Rubinstein W, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-.
2012 Sep 20 [updated 2016 May 3].

17.

Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.

Tamm R, Mägi R, Tremmel R, Winter S, Mihailov E, Smid A, Möricke A, Klein K, Schrappe M, Stanulla M, Houlston R, Weinshilboum R, Mlinarič Raščan I, Metspalu A, Milani L, Schwab M, Schaeffeler E.

Clin Pharmacol Ther. 2017 May;101(5):684-695. doi: 10.1002/cpt.540. Epub 2017 Feb 1. Review.

PMID:
27770449
18.

Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia.

Adam de Beaumais T, Jacqz-Aigrain E.

Eur J Clin Pharmacol. 2012 Sep;68(9):1233-42. doi: 10.1007/s00228-012-1251-4. Epub 2012 Mar 16. Review.

PMID:
22421815
19.

Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy.

Zur RM, Roy LM, Ito S, Beyene J, Carew C, Ungar WJ.

Pharmacogenomics J. 2016 Aug;16(4):305-11. doi: 10.1038/tpj.2016.37. Epub 2016 May 24. Review.

20.

Azathioprine Therapy and TPMT Genotype.

Dean L.

In: Pratt V, McLeod H, Dean L, Malheiro A, Rubinstein W, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-.
2012 Sep 20 [updated 2016 May 3].

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