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Items: 1 to 20 of 48

1.

Drug-like properties and the causes of poor solubility and poor permeability.

Lipinski CA.

J Pharmacol Toxicol Methods. 2000 Jul-Aug;44(1):235-49. Review.

PMID:
11274893
2.

Drug-like property concepts in pharmaceutical design.

Di L, Kerns EH, Carter GT.

Curr Pharm Des. 2009;15(19):2184-94. Review.

PMID:
19601822
3.

Progress in predicting human ADME parameters in silico.

Ekins S, Waller CL, Swaan PW, Cruciani G, Wrighton SA, Wikel JH.

J Pharmacol Toxicol Methods. 2000 Jul-Aug;44(1):251-72. Review.

PMID:
11274894
4.

Selecting oral bioavailability enhancing formulations during drug discovery and development.

Leucuta SE.

Expert Opin Drug Discov. 2014 Feb;9(2):139-50. doi: 10.1517/17460441.2014.877881. Epub 2014 Jan 3. Review.

PMID:
24387781
5.

Which in vitro screens guide the prediction of oral absorption and volume of distribution?

van de Waterbeemd H.

Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):162-6. Review.

7.

Biopharmaceutic classification system: a scientific framework for pharmacokinetic optimization in drug research.

Varma MV, Khandavilli S, Ashokraj Y, Jain A, Dhanikula A, Sood A, Thomas NS, Pillai O, Sharma P, Gandhi R, Agrawal S, Nair V, Panchagnula R.

Curr Drug Metab. 2004 Oct;5(5):375-88. Review.

PMID:
15544432
8.

Computational models to predict aqueous drug solubility, permeability and intestinal absorption.

Bergström CA.

Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):613-27. Review.

PMID:
16863428
9.

In silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption.

Bergström CA.

Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):156-61. Review.

10.

Physicochemical profiling (solubility, permeability and charge state).

Avdeef A.

Curr Top Med Chem. 2001 Sep;1(4):277-351. Review.

PMID:
11899112
11.

Solubility and permeability measurement and applications in drug discovery.

Burton PS, Goodwin JT.

Comb Chem High Throughput Screen. 2010 Feb;13(2):101-11. Review.

PMID:
20053165
12.

Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution.

Henchoz Y, Bard B, Guillarme D, Carrupt PA, Veuthey JL, Martel S.

Anal Bioanal Chem. 2009 Jun;394(3):707-29. doi: 10.1007/s00216-009-2634-y. Epub 2009 Feb 2. Review.

PMID:
19184676
13.

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

van de Waterbeemd H, Camenisch G, Folkers G, Chretien JR, Raevsky OA.

J Drug Target. 1998;6(2):151-65. Review.

PMID:
9886238
14.

Structure-ADME relationship: still a long way to go?

Hou T, Wang J.

Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):759-70. doi: 10.1517/17425255.4.6.759 . Review.

PMID:
18611116
15.

truPK -- human pharmacokinetic models for quantitative ADME prediction.

Subramanian K.

Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):555-64. Review.

PMID:
16863461
16.

Recent advances on aqueous solubility prediction.

Wang J, Hou T.

Comb Chem High Throughput Screen. 2011 Jun 1;14(5):328-38. Review.

PMID:
21470182
17.

Preclinical pharmacokinetics: an approach towards safer and efficacious drugs.

Singh SS.

Curr Drug Metab. 2006 Feb;7(2):165-82. Review.

PMID:
16472106
18.

Predictive approaches to increase absorption of compounds during lead optimisation.

Valko K, Butler J, Eddershaw P.

Expert Opin Drug Discov. 2013 Oct;8(10):1225-38. doi: 10.1517/17460441.2013.815613. Epub 2013 Jul 19. Review.

PMID:
23865945
19.

In silico prediction of ADME properties: are we making progress?

Beresford AP, Segall M, Tarbit MH.

Curr Opin Drug Discov Devel. 2004 Jan;7(1):36-42. Review.

PMID:
14982146
20.

Towards a new age of virtual ADME/TOX and multidimensional drug discovery.

Ekins S, Boulanger B, Swaan PW, Hupcey MA.

Mol Divers. 2002;5(4):255-75. Review.

PMID:
12549676

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