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Brain Res Mol Brain Res. 1999 May 7;68(1-2):193-7.

Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice.

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1
Section on Functional Neuroanatomy, Intramural Research Program, NIMH, Bethesda, MD 20892, USA.

Abstract

Mu and delta opioid receptors were labeled in enkephalin knockout mice by quantitative autoradiography. Discrete, large increases (100-300%) were found in limbic forebrain structures for mu binding and striatum and pallidum for delta binding. The up-regulation of opioid receptors may reflect a form of 'denervation supersensitivity. ' The receptor up-regulation in limbic areas is consistent with the increased emotional and aggressive behaviors observed in the enkephalin knockout mice.

PMID:
10320798
[Indexed for MEDLINE]
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