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From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.

Koutsogiannaki S, Schaefers MM, Okuno T, Ohba M, Yokomizo T, Priebe GP, DiNardo JA, Sulpicio SG, Yuki K.

Toxicol Sci. 2017 Apr 1;156(2):402-411. doi: 10.1093/toxsci/kfw261.


Complement: an overview for the clinician.

Varela JC, Tomlinson S.

Hematol Oncol Clin North Am. 2015 Jun;29(3):409-27. doi: 10.1016/j.hoc.2015.02.001. Epub 2015 Apr 4. Review.


Sepsis pathophysiology and anesthetic consideration.

Yuki K, Murakami N.

Cardiovasc Hematol Disord Drug Targets. 2015;15(1):57-69. Review.


Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.

Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK.

Front Genet. 2014 May 9;5:125. doi: 10.3389/fgene.2014.00125. eCollection 2014.


Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Faridi MH, Altintas MM, Gomez C, Duque JC, Vazquez-Padron RI, Gupta V.

Biochim Biophys Acta. 2013 Jun;1830(6):3696-710. doi: 10.1016/j.bbagen.2013.02.018. Epub 2013 Feb 26.


Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model.

Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M.

J Anesth. 2013 Apr;27(2):261-8. doi: 10.1007/s00540-012-1508-1. Epub 2012 Oct 25.


Hematologically important mutations: leukocyte adhesion deficiency (first update).

van de Vijver E, Maddalena A, Sanal Ö, Holland SM, Uzel G, Madkaikar M, de Boer M, van Leeuwen K, Köker MY, Parvaneh N, Fischer A, Law SK, Klein N, Tezcan FI, Unal E, Patiroglu T, Belohradsky BH, Schwartz K, Somech R, Kuijpers TW, Roos D.

Blood Cells Mol Dis. 2012 Jan 15;48(1):53-61. doi: 10.1016/j.bcmd.2011.10.004. Epub 2011 Nov 30. Review.


Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.

Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Schürer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V.

Sci Signal. 2011 Sep 6;4(189):ra57. doi: 10.1126/scisignal.2001811.


On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3.

Costantini C, Micheletti A, Calzetti F, Perbellini O, Tamassia N, Albanesi C, Vermi W, Cassatella MA.

Haematologica. 2011 Oct;96(10):1543-7. doi: 10.3324/haematol.2011.044578. Epub 2011 Jun 28.


A rare association between leukocyte adhesion deficiency type I and psoriasis in humans.

El-Sayed ZA, El-Ghoneimy DH, Abd-Allah H, Afifi HM.

Allergy Asthma Immunol Res. 2011 Apr;3(2):138-40. doi: 10.4168/aair.2011.3.2.138. Epub 2011 Feb 9.


The effect of gentamicin-induced readthrough on a novel premature termination codon of CD18 leukocyte adhesion deficiency patients.

Simon AJ, Lev A, Wolach B, Gavrieli R, Amariglio N, Rosenthal E, Gazit E, Eyal E, Rechavi G, Somech R.

PLoS One. 2010 Nov 16;5(11):e13659. doi: 10.1371/journal.pone.0013659.


Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

Chen X, Xie C, Nishida N, Li Z, Walz T, Springer TA.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14727-32. doi: 10.1073/pnas.1008663107. Epub 2010 Aug 2.


Identification of novel agonists of the integrin CD11b/CD18.

Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Schürer S, Gupta V.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6902-6. doi: 10.1016/j.bmcl.2009.10.077. Epub 2009 Oct 22.


Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice.

Oreshkova T, Wang H, Seier AM, Sindrilaru A, Varga G, Grabbe S, Scharffetter-Kochanek K, Peters T.

Immunology. 2009 Oct;128(2):271-86. doi: 10.1111/j.1365-2567.2009.03116.x.


Structural modifications of ICAM-1 cyclic peptides to improve the activity to inhibit heterotypic adhesion of T cells.

Iskandarsyah, Tejo BA, Tambunan US, Verkhivker G, Siahaan TJ.

Chem Biol Drug Des. 2008 Jul;72(1):27-33. doi: 10.1111/j.1747-0285.2008.00676.x. Epub 2008 Jun 11.


Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function.

Gupta V, Alonso JL, Sugimori T, Essafi M, Xiong JP, Arnaout MA.

J Immunol. 2008 Feb 1;180(3):1713-8. Erratum in: J Immunol. 2008 Mar 1;180(5):3613. Issafi, Makram [corrected to Essafi, Makram].


The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.

Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA.

Blood. 2007 Apr 15;109(8):3513-20. Epub 2006 Dec 14.


Infections in patients with inherited defects in phagocytic function.

Andrews T, Sullivan KE.

Clin Microbiol Rev. 2003 Oct;16(4):597-621. Review.

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