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A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel.

Bai F, Pi X, Li P, Zhou P, Yang H, Wang X, Li M, Gao Z, Jiang H.

Front Pharmacol. 2018 Mar 9;9:150. doi: 10.3389/fphar.2018.00150. eCollection 2018.


The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport.

Fisi V, Miseta A, Nagy T.

Oxid Med Cell Longev. 2017;2017:1308692. doi: 10.1155/2017/1308692. Epub 2017 Dec 31. Review.


Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies.

Oyrer J, Maljevic S, Scheffer IE, Berkovic SF, Petrou S, Reid CA.

Pharmacol Rev. 2018 Jan;70(1):142-173. doi: 10.1124/pr.117.014456. Review.


Two Novel KCNQ2 Mutations in 2 Families With Benign Familial Neonatal Convulsions.

Al Yazidi G, Shevell MI, Srour M.

Child Neurol Open. 2017 Feb 23;4:2329048X17691396. doi: 10.1177/2329048X17691396. eCollection 2017 Jan-Dec.


Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy.

Wei F, Yan LM, Su T, He N, Lin ZJ, Wang J, Shi YW, Yi YH, Liao WP.

Neurosci Bull. 2017 Aug;33(4):455-477. doi: 10.1007/s12264-017-0134-1. Epub 2017 May 9. Review.


Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia.

Bruce HA, Kochunov P, Paciga SA, Hyde CL, Chen X, Xie Z, Zhang B, Xi HS, O'Donnell P, Whelan C, Schubert CR, Bellon A, Ament SA, Shukla DK, Du X, Rowland LM, O'Neill H, Hong LE.

Genes Brain Behav. 2017 Jun;16(5):515-521. doi: 10.1111/gbb.12372. Epub 2017 Mar 13.


Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H.

Mulkey SB, Ben-Zeev B, Nicolai J, Carroll JL, Grønborg S, Jiang YH, Joshi N, Kelly M, Koolen DA, Mikati MA, Park K, Pearl PL, Scheffer IE, Spillmann RC, Taglialatela M, Vieker S, Weckhuysen S, Cooper EC, Cilio MR.

Epilepsia. 2017 Mar;58(3):436-445. doi: 10.1111/epi.13676. Epub 2017 Jan 31.


Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.

Taylor KC, Sanders CR.

Biochim Biophys Acta. 2017 Apr;1859(4):586-597. doi: 10.1016/j.bbamem.2016.10.023. Epub 2016 Nov 4. Review.


Modulation of Kv7 channels and excitability in the brain.

Greene DL, Hoshi N.

Cell Mol Life Sci. 2017 Feb;74(3):495-508. doi: 10.1007/s00018-016-2359-y. Epub 2016 Sep 19. Review.


Phosphorylation regulates the sensitivity of voltage-gated Kv7.2 channels towards phosphatidylinositol-4,5-bisphosphate.

Salzer I, Erdem FA, Chen WQ, Heo S, Koenig X, Schicker KW, Kubista H, Lubec G, Boehm S, Yang JW.

J Physiol. 2017 Feb 1;595(3):759-776. doi: 10.1113/JP273274. Epub 2016 Nov 7.


Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression.

Kim HJ, Jeong MH, Kim KR, Jung CY, Lee SY, Kim H, Koh J, Vuong TA, Jung S, Yang H, Park SK, Choi D, Kim SH, Kang K, Sohn JW, Park JM, Jeon D, Koo SH, Ho WK, Kang JS, Kim ST, Cho H.

Elife. 2016 Jul 28;5. pii: e17159. doi: 10.7554/eLife.17159.


Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease.

Lehnert S, Hartmann S, Hessler S, Adelsberger H, Huth T, Alzheimer C.

Channels (Austin). 2016 Sep 2;10(5):365-378. Epub 2016 Jun 2. Review.


Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations.

Ihara Y, Tomonoh Y, Deshimaru M, Zhang B, Uchida T, Ishii A, Hirose S.

PLoS One. 2016 Feb 24;11(2):e0150095. doi: 10.1371/journal.pone.0150095. eCollection 2016.


KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.

Schütze S, Orozco IJ, Jentsch TJ.

J Biol Chem. 2016 Mar 11;291(11):5566-75. doi: 10.1074/jbc.M115.681098. Epub 2016 Jan 5.


Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.

Mani BK, Robakowski C, Brueggemann LI, Cribbs LL, Tripathi A, Majetschak M, Byron KL.

Mol Pharmacol. 2016 Mar;89(3):323-34. doi: 10.1124/mol.115.101758. Epub 2015 Dec 23.


KCNQ potassium channels in sensory system and neural circuits.

Wang JJ, Li Y.

Acta Pharmacol Sin. 2016 Jan;37(1):25-33. doi: 10.1038/aps.2015.131. Epub 2015 Dec 21. Review.


The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.

Syeda R, Santos JS, Montal M.

J Biol Chem. 2016 Feb 5;291(6):2931-7. doi: 10.1074/jbc.M115.683185. Epub 2015 Dec 1.


Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation.

Chen L, Zhang Q, Qiu Y, Li Z, Chen Z, Jiang H, Li Y, Yang H.

Sci Rep. 2015 Oct 15;5:15079. doi: 10.1038/srep15079.


Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential.

Wolfart J, Laker D.

Front Physiol. 2015 Jun 15;6:168. doi: 10.3389/fphys.2015.00168. eCollection 2015. Review.


The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.

Abbott GW.

Gene. 2015 Sep 15;569(2):162-72. doi: 10.1016/j.gene.2015.06.061. Epub 2015 Jun 27. Review.

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