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Items: 1 to 20 of 431


Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.

Tian L, Kim MS, Li H, Wang J, Yang W.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):507-512. doi: 10.1073/pnas.1719746115. Epub 2018 Jan 2.


Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway.

Álvarez M, Nevot M, Mendieta J, Martínez MA, Menéndez-Arias L.

J Biol Chem. 2018 Feb 16;293(7):2247-2259. doi: 10.1074/jbc.RA117.000177. Epub 2017 Dec 22.


The mechano-chemistry of a monomeric reverse transcriptase.

Malik O, Khamis H, Rudnizky S, Kaplan A.

Nucleic Acids Res. 2017 Dec 15;45(22):12954-12962. doi: 10.1093/nar/gkx1168.


Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase.

Figiel M, Krepl M, Park S, Poznański J, Skowronek K, Gołąb A, Ha T, Šponer J, Nowotny M.

J Biol Chem. 2018 Jan 5;293(1):191-202. doi: 10.1074/jbc.M117.798256. Epub 2017 Nov 9.


Site-Specific Disulfide Crosslinked Nucleosomes with Enhanced Stability.

Frouws TD, Barth PD, Richmond TJ.

J Mol Biol. 2018 Jan 5;430(1):45-57. doi: 10.1016/j.jmb.2017.10.029. Epub 2017 Nov 4.


Calcium-driven DNA synthesis by a high-fidelity DNA polymerase.

Ralec C, Henry E, Lemor M, Killelea T, Henneke G.

Nucleic Acids Res. 2017 Dec 1;45(21):12425-12440. doi: 10.1093/nar/gkx927.


Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.

Kankanala J, Kirby KA, Huber AD, Casey MC, Wilson DJ, Sarafianos SG, Wang Z.

Eur J Med Chem. 2017 Dec 1;141:149-161. doi: 10.1016/j.ejmech.2017.09.054. Epub 2017 Sep 28.


Pyrophosphate Release in the Protein HIV Reverse Transcriptase.

Atis M, Johnson KA, Elber R.

J Phys Chem B. 2017 Oct 19;121(41):9557-9565. doi: 10.1021/acs.jpcb.7b08320. Epub 2017 Oct 4.


Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase.

Ilic S, Akabayov SR, Froimovici R, Meiry R, Vilenchik D, Hernandez A, Arthanari H, Akabayov B.

Sci Rep. 2017 Jul 19;7(1):5797. doi: 10.1038/s41598-017-05534-3.


Combining Graphical and Analytical Methods with Molecular Simulations To Analyze Time-Resolved FRET Measurements of Labeled Macromolecules Accurately.

Peulen TO, Opanasyuk O, Seidel CAM.

J Phys Chem B. 2017 Sep 7;121(35):8211-8241. doi: 10.1021/acs.jpcb.7b03441. Epub 2017 Aug 28.


The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand.

Zhao C, Pyle AM.

Curr Opin Struct Biol. 2017 Dec;47:30-39. doi: 10.1016/ Epub 2017 May 18. Review.


The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.

Lai AG, Pouchkina-Stantcheva N, Di Donfrancesco A, Kildisiute G, Sahu S, Aboobaker AA.

BMC Evol Biol. 2017 Apr 26;17(1):107. doi: 10.1186/s12862-017-0949-4.


Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.

Das K, Martinez SE, Arnold E.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00224-17. doi: 10.1128/AAC.00224-17. Print 2017 Jun.


Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.

Tang J, Vernekar SKV, Chen YL, Miller L, Huber AD, Myshakina N, Sarafianos SG, Parniak MA, Wang Z.

Eur J Med Chem. 2017 Jun 16;133:85-96. doi: 10.1016/j.ejmech.2017.03.059. Epub 2017 Mar 29.


Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.

Álvarez M, Sebastián-Martín A, García-Marquina G, Menéndez-Arias L.

Sci Rep. 2017 Mar 23;7:44834. doi: 10.1038/srep44834.


HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

Banerjee P, Chakraborty A, Mondal RK, Khatun M, Datta S, Das K, Pandit P, Mukherjee S, Banerjee S, Ghosh S, Chakrabarti S, Chowdhury A, Datta S.

Sci Rep. 2017 Mar 17;7:44742. doi: 10.1038/srep44742.


The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase.

Shu B, Gong P.

RNA Biol. 2017 Oct 3;14(10):1314-1319. doi: 10.1080/15476286.2017.1300221. Epub 2017 Mar 1.


Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase.

Figiel M, Krepl M, Poznanski J, Golab A, Šponer J, Nowotny M.

Nucleic Acids Res. 2017 Apr 7;45(6):3341-3352. doi: 10.1093/nar/gkx004.


Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites.

Perera L, Beard WA, Pedersen LG, Wilson SH.

Inorg Chem. 2017 Jan 3;56(1):313-320. doi: 10.1021/acs.inorgchem.6b02189. Epub 2016 Dec 15.


Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.

Achuthan V, Singh K, DeStefano JJ.

Biochemistry. 2017 Jan 10;56(1):33-46. doi: 10.1021/acs.biochem.6b00943. Epub 2016 Dec 27.

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