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Items: 1 to 20 of 56

1.

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.

Chiang EY, Li T, Jeet S, Peng I, Zhang J, Lee WP, DeVoss J, Caplazi P, Chen J, Warming S, Hackos DH, Mukund S, Koth CM, Grogan JL.

Nat Commun. 2017 Mar 1;8:14644. doi: 10.1038/ncomms14644.

2.

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers.

Fung-Leung WP, Edwards W, Liu Y, Ngo K, Angsana J, Castro G, Wu N, Liu X, Swanson RV, Wickenden AD.

PLoS One. 2017 Jan 20;12(1):e0170102. doi: 10.1371/journal.pone.0170102. eCollection 2017.

3.

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.

Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11501-11506. Epub 2016 Sep 23.

4.

Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation.

Kang JA, Park SH, Jeong SP, Han MH, Lee CR, Lee KM, Kim N, Song MR, Choi M, Ye M, Jung G, Lee WW, Eom SH, Park CS, Park SG.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8771-6. doi: 10.1073/pnas.1502166113. Epub 2016 Jul 20.

5.

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons.

Lazcano-Pérez F, Castro H, Arenas I, García DE, González-Muñoz R, Arreguín-Espinosa R.

Toxins (Basel). 2016 May 5;8(5). pii: E135. doi: 10.3390/toxins8050135.

6.

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases.

Ye F, Hu Y, Yu W, Xie Z, Hu J, Cao Z, Li W, Wu Y.

Toxins (Basel). 2016 Apr 19;8(4):115. doi: 10.3390/toxins8040115.

7.

Computational Studies of Venom Peptides Targeting Potassium Channels.

Chen R, Chung SH.

Toxins (Basel). 2015 Dec 1;7(12):5194-211. doi: 10.3390/toxins7124877. Review.

8.

Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display.

Zhao R, Dai H, Mendelman N, Cuello LG, Chill JH, Goldstein SA.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7013-21. doi: 10.1073/pnas.1514728112. Epub 2015 Dec 1.

9.

Roles of lymphocyte kv1.3-channels in the pathogenesis of renal diseases and novel therapeutic implications of targeting the channels.

Kazama I.

Mediators Inflamm. 2015;2015:436572. doi: 10.1155/2015/436572. Epub 2015 Mar 18. Review.

10.

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Chang SC, Huq R, Chhabra S, Beeton C, Pennington MW, Smith BJ, Norton RS.

FEBS J. 2015 Jun;282(12):2247-59. doi: 10.1111/febs.13294. Epub 2015 Apr 23.

11.

Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY.

Kuzmenkov AI, Vassilevski AA, Kudryashova KS, Nekrasova OV, Peigneur S, Tytgat J, Feofanov AV, Kirpichnikov MP, Grishin EV.

J Biol Chem. 2015 May 8;290(19):12195-209. doi: 10.1074/jbc.M115.637611. Epub 2015 Mar 19.

12.

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.

Pennington MW, Chang SC, Chauhan S, Huq R, Tajhya RB, Chhabra S, Norton RS, Beeton C.

Mar Drugs. 2015 Jan 16;13(1):529-42. doi: 10.3390/md13010529.

13.

Nemertean toxin genes revealed through transcriptome sequencing.

Whelan NV, Kocot KM, Santos SR, Halanych KM.

Genome Biol Evol. 2014 Nov 27;6(12):3314-25. doi: 10.1093/gbe/evu258.

14.

Early engineering approaches to improve peptide developability and manufacturability.

Furman JL, Chiu M, Hunter MJ.

AAPS J. 2015 Jan;17(1):111-20. doi: 10.1208/s12248-014-9681-9. Epub 2014 Oct 23. Review.

15.

Conformational flexibility in the binding surface of the potassium channel blocker ShK.

Sher I, Chang SC, Li Y, Chhabra S, Palmer AG 3rd, Norton RS, Chill JH.

Chembiochem. 2014 Nov 3;15(16):2402-10. doi: 10.1002/cbic.201402295. Epub 2014 Sep 18.

16.

Ion channel engineering: perspectives and strategies.

Subramanyam P, Colecraft HM.

J Mol Biol. 2015 Jan 16;427(1):190-204. doi: 10.1016/j.jmb.2014.09.001. Epub 2014 Sep 7. Review.

17.

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG.

FASEB J. 2014 Sep;28(9):3952-64. doi: 10.1096/fj.14-251967. Epub 2014 Jun 2.

18.

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel.

Sabogal-Arango A, Barreto GE, Ramírez-Sánchez D, González-Mendoza J, Barreto V, Morales L, González J.

Bioinform Biol Insights. 2014 Apr 15;8:73-81. doi: 10.4137/BBI.S13403. eCollection 2014.

19.

Ionic mechanisms of microsecond-scale spike timing in single cells.

Markham MR, Zakon HH.

J Neurosci. 2014 May 7;34(19):6668-78. doi: 10.1523/JNEUROSCI.0615-14.2014.

20.

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation.

Rashid MH, Heinzelmann G, Huq R, Tajhya RB, Chang SC, Chhabra S, Pennington MW, Beeton C, Norton RS, Kuyucak S.

PLoS One. 2013 Nov 7;8(11):e78712. doi: 10.1371/journal.pone.0078712. eCollection 2013.

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