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Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis.

Procaccia S, Ordan M, Cohen I, Bendetz-Nezer S, Seger R.

Sci Rep. 2017 Feb 22;7:43078. doi: 10.1038/srep43078.


Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.

Mitra S, Ghosh B, Gayen N, Roy J, Mandal AK.

J Biol Chem. 2016 Nov 18;291(47):24579-24593. Epub 2016 Oct 4.


RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.

Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y.

Oncogene. 2016 Dec 8;35(49):6319-6329. doi: 10.1038/onc.2016.163. Epub 2016 May 16.


Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.

Zuo Y, Oh W, Ulu A, Frost JA.

Mol Endocrinol. 2016 Mar;30(3):278-89. doi: 10.1210/me.2015-1294. Epub 2015 Dec 17. Review.


RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.

Tam SY, Lilla JN, Chen CC, Kalesnikoff J, Tsai M.

PLoS One. 2015 Nov 20;10(11):e0142935. doi: 10.1371/journal.pone.0142935. eCollection 2015.


Kinase-independent role for CRAF-driving tumour radioresistance via CHK2.

Advani SJ, Camargo MF, Seguin L, Mielgo A, Anand S, Hicks AM, Aguilera J, Franovic A, Weis SM, Cheresh DA.

Nat Commun. 2015 Sep 3;6:8154. doi: 10.1038/ncomms9154.


IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.

Mombelli S, Cochaud S, Merrouche Y, Garbar C, Antonicelli F, Laprevotte E, Alberici G, Bonnefoy N, Eliaou JF, Bastid J, Bensussan A, Giustiniani J.

Sci Rep. 2015 Jul 8;5:11874. doi: 10.1038/srep11874.


Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation.

Jossé R, Zhang YW, Giroux V, Ghosh AK, Luo J, Pommier Y.

Mar Drugs. 2015 Jun 5;13(6):3625-39. doi: 10.3390/md13063625.


IQGAP1: insights into the function of a molecular puppeteer.

Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S.

Mol Immunol. 2015 Jun;65(2):336-49. doi: 10.1016/j.molimm.2015.02.012. Epub 2015 Feb 28. Review.


Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.

Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM.

Oncotarget. 2014 Nov 15;5(21):10251-70.


P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.

Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH, Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW.

Oncogene. 2015 Jul 23;34(30):3968-76. doi: 10.1038/onc.2014.328. Epub 2014 Oct 6.


Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma.

Hill B, De Melo J, Yan J, Kapoor A, He L, Cutz JC, Feng X, Bakhtyar N, Tang D.

Oncotarget. 2014 Sep 15;5(17):7406-19.


SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells.

Cao Z, Li X, Li J, Kang B, Chen J, Luo W, Huang C.

Mol Oncol. 2014 Mar;8(2):285-96. doi: 10.1016/j.molonc.2013.11.006. Epub 2013 Dec 3.


Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling.

Ke Y, Lei M, Wang X, Solaro RJ.

Front Pharmacol. 2013 Sep 27;4:116. doi: 10.3389/fphar.2013.00116. Review.


A novel noncanonical signaling pathway for the μ-opioid receptor.

Zhang L, Loh HH, Law PY.

Mol Pharmacol. 2013 Dec;84(6):844-53. doi: 10.1124/mol.113.088278. Epub 2013 Sep 23.


Effects of butyltins on mitogen-activated-protein kinase kinase kinase and Ras activity in human natural killer cells.

Celada LJ, Whalen MM.

J Appl Toxicol. 2014 Sep;34(9):1002-11. doi: 10.1002/jat.2921. Epub 2013 Sep 5.


Allosteric activation of functionally asymmetric RAF kinase dimers.

Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS.

Cell. 2013 Aug 29;154(5):1036-46. doi: 10.1016/j.cell.2013.07.046.


Hierarchical scaffolding of an ERK1/2 activation pathway.

Vetterkind S, Poythress RH, Lin QQ, Morgan KG.

Cell Commun Signal. 2013 Aug 29;11:65. doi: 10.1186/1478-811X-11-65.


AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.

Hong SK, Jeong JH, Chan AM, Park JI.

Exp Cell Res. 2013 Jul 15;319(12):1732-43. doi: 10.1016/j.yexcr.2013.05.008. Epub 2013 May 20.

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