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Items: 1 to 20 of 33


Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition.

Ariumi Y.

Front Chem. 2016 Jun 28;4:28. doi: 10.3389/fchem.2016.00028. Review.


The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations.

Kines KJ, Sokolowski M, deHaro DL, Christian CM, Baddoo M, Smither ME, Belancio VP.

Mob DNA. 2016 Apr 19;7:8. doi: 10.1186/s13100-016-0064-x.


Multiple LINEs of retrotransposon silencing mechanisms in the mammalian germline.

Yang F, Wang PJ.

Semin Cell Dev Biol. 2016 Nov;59:118-125. doi: 10.1016/j.semcdb.2016.03.001. Review.


The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.

Richardson SR, Doucet AJ, Kopera HC, Moldovan JB, Garcia-Perez JL, Moran JV.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0061-2014. doi: 10.1128/microbiolspec.MDNA3-0061-2014. Review.


Phosphorylation of ORF1p is required for L1 retrotransposition.

Cook PR, Jones CE, Furano AV.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4298-303. doi: 10.1073/pnas.1416869112.


piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.

Pezic D, Manakov SA, Sachidanandam R, Aravin AA.

Genes Dev. 2014 Jul 1;28(13):1410-28. doi: 10.1101/gad.240895.114.


An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition.

Li J, Kannan M, Trivett AL, Liao H, Wu X, Akagi K, Symer DE.

Nucleic Acids Res. 2014 Apr;42(7):4546-62. doi: 10.1093/nar/gku091.


Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline.

Crichton JH, Dunican DS, Maclennan M, Meehan RR, Adams IR.

Cell Mol Life Sci. 2014 May;71(9):1581-605. doi: 10.1007/s00018-013-1468-0. Review.


The Microprocessor controls the activity of mammalian retrotransposons.

Heras SR, Macias S, Plass M, Fernandez N, Cano D, Eyras E, Garcia-Perez JL, Cáceres JF.

Nat Struct Mol Biol. 2013 Oct;20(10):1173-81. doi: 10.1038/nsmb.2658.


Revisiting the evolution of mouse LINE-1 in the genomic era.

Sookdeo A, Hepp CM, McClure MA, Boissinot S.

Mob DNA. 2013 Jan 3;4(1):3. doi: 10.1186/1759-8753-4-3.


Retrofitting the genome: L1 extinction follows endogenous retroviral expansion in a group of muroid rodents.

Erickson IK, Cantrell MA, Scott L, Wichman HA.

J Virol. 2011 Dec;85(23):12315-23. doi: 10.1128/JVI.05180-11.


Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.

Ikeda T, Abd El Galil KH, Tokunaga K, Maeda K, Sata T, Sakaguchi N, Heidmann T, Koito A.

Nucleic Acids Res. 2011 Jul;39(13):5538-54. doi: 10.1093/nar/gkr124.


The impact of CpG island on defining transcriptional activation of the mouse L1 retrotransposable elements.

Lee SH, Cho SY, Shannon MF, Fan J, Rangasamy D.

PLoS One. 2010 Jun 29;5(6):e11353. doi: 10.1371/journal.pone.0011353.


A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage?

St Laurent G 3rd, Hammell N, McCaffrey TA.

Mech Ageing Dev. 2010 May;131(5):299-305. doi: 10.1016/j.mad.2010.03.008. Review.


Environmental influence on L1 retrotransposons in the adult hippocampus.

Muotri AR, Zhao C, Marchetto MC, Gage FH.

Hippocampus. 2009 Oct;19(10):1002-7. doi: 10.1002/hipo.20564.


The protist Trichomonas vaginalis harbors multiple lineages of transcriptionally active Mutator-like elements.

Lopes FR, Silva JC, Benchimol M, Costa GG, Pereira GA, Carareto CM.

BMC Genomics. 2009 Jul 21;10:330. doi: 10.1186/1471-2164-10-330.


The L1 retrotransposition assay: a retrospective and toolkit.

Rangwala SH, Kazazian HH Jr.

Methods. 2009 Nov;49(3):219-26. doi: 10.1016/j.ymeth.2009.04.012. Review.


AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity.

MacDuff DA, Demorest ZL, Harris RS.

Nucleic Acids Res. 2009 Apr;37(6):1854-67. doi: 10.1093/nar/gkp030.


Murine endogenous retroviruses.

Stocking C, Kozak CA.

Cell Mol Life Sci. 2008 Nov;65(21):3383-98. doi: 10.1007/s00018-008-8497-0. Review.


A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity.

Martin SL, Bushman D, Wang F, Li PW, Walker A, Cummiskey J, Branciforte D, Williams MC.

Nucleic Acids Res. 2008 Oct;36(18):5845-54. doi: 10.1093/nar/gkn554.

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