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Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson's Disease.

Chen T, Tan J, Wan Z, Zou Y, Afewerky HK, Zhang Z, Zhang T.

Int J Mol Sci. 2017 Nov 23;18(12). pii: E2507. doi: 10.3390/ijms18122507.


Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.

Maiti P, Manna J, Dunbar GL.

Transl Neurodegener. 2017 Oct 25;6:28. doi: 10.1186/s40035-017-0099-z. eCollection 2017. Review.


An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.

Li Y, Xie P, Lu L, Wang J, Diao L, Liu Z, Guo F, He Y, Liu Y, Huang Q, Liang H, Li D, He F.

Nat Commun. 2017 Aug 24;8(1):347. doi: 10.1038/s41467-017-00299-9.


Protection against neurodegenerative disease on Earth and in space.

Takamatsu Y, Koike W, Takenouchi T, Sugama S, Wei J, Waragai M, Sekiyama K, Hashimoto M.

NPJ Microgravity. 2016 Apr 7;2:16013. doi: 10.1038/npjmgrav.2016.13. eCollection 2016.


Role of Apolipoproteins and α-Synuclein in Parkinson's Disease.

Emamzadeh FN.

J Mol Neurosci. 2017 Aug;62(3-4):344-355. doi: 10.1007/s12031-017-0942-9. Epub 2017 Jul 10. Review.


UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.

Luo Y, He J, Yang C, Orange M, Ren X, Blair N, Tan T, Yang JM, Zhu H.

J Cell Biochem. 2018 Jan;119(1):691-700. doi: 10.1002/jcb.26232. Epub 2017 Jul 31.


Cell Biology and Pathophysiology of α-Synuclein.

Burré J, Sharma M, Südhof TC.

Cold Spring Harb Perspect Med. 2017 Jan 20. pii: a024091. doi: 10.1101/cshperspect.a024091. [Epub ahead of print]


Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

Lahut S, Gispert S, Ömür Ö, Depboylu C, Seidel K, Domínguez-Bautista JA, Brehm N, Tireli H, Hackmann K, Pirkevi C, Leube B, Ries V, Reim K, Brose N, den Dunnen WF, Johnson M, Wolf Z, Schindewolf M, Schrempf W, Reetz K, Young P, Vadasz D, Frangakis AS, Schröck E, Steinmetz H, Jendrach M, Rüb U, Başak AN, Oertel W, Auburger G.

Dis Model Mech. 2017 May 1;10(5):619-631. doi: 10.1242/dmm.028035. Epub 2017 Jan 20.


High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx.

Ding Z, Fu Z, Xu C, Wang Y, Wang Y, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y.

Cell Res. 2017 Mar;27(3):373-385. doi: 10.1038/cr.2017.12. Epub 2017 Jan 20.


Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function.

Hwang CJ, Kim YE, Son DJ, Park MH, Choi DY, Park PH, Hellström M, Han SB, Oh KW, Park EK, Hong JT.

Redox Biol. 2017 Apr;11:456-468. doi: 10.1016/j.redox.2016.12.008. Epub 2016 Dec 8.


Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.

Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu IC, Vasconcelos B, Pierrot N, Faelth-Savitski M, Kienlen-Campard P, Octave JN, Bantscheff M, Drewes G, Moechars D, Dewachter I.

Acta Neuropathol. 2017 May;133(5):731-749. doi: 10.1007/s00401-016-1663-9. Epub 2017 Jan 12.


Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases.

Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X.

Front Aging Neurosci. 2016 Dec 15;8:303. doi: 10.3389/fnagi.2016.00303. eCollection 2016. Review.


Bcl-2 homologue Debcl enhances α-synuclein-induced phenotypes in Drosophila.

M'Angale PG, Staveley BE.

PeerJ. 2016 Sep 15;4:e2461. doi: 10.7717/peerj.2461. eCollection 2016.


Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction.

Bishop P, Rocca D, Henley JM.

Biochem J. 2016 Aug 15;473(16):2453-62. doi: 10.1042/BCJ20160082. Review.


Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease.

Öhrfelt A, Johansson P, Wallin A, Andreasson U, Zetterberg H, Blennow K, Svensson J.

Dement Geriatr Cogn Dis Extra. 2016 Jul 15;6(2):283-94. doi: 10.1159/000447239. eCollection 2016 May-Aug.


Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.

Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ.

Aging Cell. 2016 Oct;15(5):924-39. doi: 10.1111/acel.12501. Epub 2016 Jul 23.


Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives.

Sarkar S, Raymick J, Imam S.

Int J Mol Sci. 2016 Jun 8;17(6). pii: E904. doi: 10.3390/ijms17060904. Review.


The Evolution of Genetics: Alzheimer's and Parkinson's Diseases.

Singleton A, Hardy J.

Neuron. 2016 Jun 15;90(6):1154-1163. doi: 10.1016/j.neuron.2016.05.040. Review.


Absence of UCHL 1 function leads to selective motor neuropathy.

Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH.

Ann Clin Transl Neurol. 2016 Mar 7;3(5):331-45. doi: 10.1002/acn3.298. eCollection 2016 May.


The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.

M'Angale PG, Staveley BE.

BMC Neurosci. 2016 May 18;17(1):24. doi: 10.1186/s12868-016-0261-z.

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