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Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.

Oshima J, Sidorova JM, Monnat RJ Jr.

Ageing Res Rev. 2016 Mar 15. pii: S1568-1637(16)30026-5. doi: 10.1016/j.arr.2016.03.002. [Epub ahead of print] Review.


Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway.

Su F, Bhattacharya S, Abdisalaam S, Mukherjee S, Yajima H, Yang Y, Mishra R, Srinivasan K, Ghose S, Chen DJ, Yannone SM, Asaithamby A.

Oncotarget. 2016 Jan 5;7(1):46-65. doi: 10.18632/oncotarget.6659.


The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events.

Edwards DN, Machwe A, Chen L, Bohr VA, Orren DK.

Nat Commun. 2015 Sep 30;6:8331. doi: 10.1038/ncomms9331.


A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies.

Agrelo R, Sutz MA, Setien F, Aldunate F, Esteller M, Da Costa V, Achenbach R.

Epigenetics. 2015;10(4):329-41. doi: 10.1080/15592294.2015.1027853.


Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress.

Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SM, Chen DJ, Asaithamby A.

Cell Rep. 2014 Nov 20;9(4):1387-401. doi: 10.1016/j.celrep.2014.10.025. Epub 2014 Nov 6.


Multimerization domains are associated with apparent strand exchange activity in BLM and WRN DNA helicases.

Chen CF, Brill SJ.

DNA Repair (Amst). 2014 Oct;22:137-46. doi: 10.1016/j.dnarep.2014.07.015. Epub 2014 Sep 3.


The dissolution of double Holliday junctions.

Bizard AH, Hickson ID.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a016477. doi: 10.1101/cshperspect.a016477. Review.


Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities.

Lozada E, Yi J, Luo J, Orren DK.

Biogerontology. 2014 Aug;15(4):347-66. doi: 10.1007/s10522-014-9506-3. Epub 2014 Jun 26.


Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.

Edwards DN, Orren DK, Machwe A.

Nucleic Acids Res. 2014 Jul;42(12):7748-61. doi: 10.1093/nar/gku454. Epub 2014 May 31.


Werner syndrome protein positively regulates XRCC4-like factor transcription.

Liu D, Deng X, Yuan C, Chen L, Cong Y, Xu X.

Mol Med Rep. 2014 May;9(5):1648-52. doi: 10.3892/mmr.2014.2030. Epub 2014 Mar 10.


Human RecQ helicases in DNA repair, recombination, and replication.

Croteau DL, Popuri V, Opresko PL, Bohr VA.

Annu Rev Biochem. 2014;83:519-52. doi: 10.1146/annurev-biochem-060713-035428. Epub 2014 Mar 3. Review.


Ethnic-Specific WRN Mutations in South Asian Werner Syndrome Patients: Potential Founder Effect in Patients with Indian or Pakistani Ancestry.

Saha B, Lessel D, Nampoothiri S, Rao AS, Hisama FM, Peter D, Bennett C, Nürnberg G, Nürnberg P, Martin GM, Kubisch C, Oshima J.

Mol Genet Genomic Med. 2013 May 1;1(1):7-14.


Chromatin remodeling, DNA damage repair and aging.

Liu B, Yip RKh, Zhou Z.

Curr Genomics. 2012 Nov;13(7):533-47. doi: 10.2174/138920212803251373.


Crystal structure of the protein from Arabidopsis thaliana gene At5g06450, a putative DnaQ-like exonuclease domain-containing protein with homohexameric assembly.

Smith DW, Han MR, Park JS, Kim KR, Yeom T, Lee JY, Kim DJ, Bingman CA, Kim HJ, Jo K, Han BW, Phillips GN Jr.

Proteins. 2013 Sep;81(9):1669-75. doi: 10.1002/prot.24315. Epub 2013 Jun 17.


Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?

Strande NT, Waters CA, Ramsden DA.

Genome Integr. 2012 Dec 31;3(1):10. doi: 10.1186/2041-9414-3-10.


Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry.

Mangerich A, Veith S, Popp O, Fahrer J, Martello R, Bohr VA, Bürkle A.

Mech Ageing Dev. 2012 Aug;133(8):575-9. doi: 10.1016/j.mad.2012.06.005. Epub 2012 Jul 2.


Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.

Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, König C, Furrer A, Bohr VA, Hübscher U, Janscak P.

Nucleic Acids Res. 2012 Sep 1;40(17):8449-59. Epub 2012 Jun 29.


Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.

Indig FE, Rybanska I, Karmakar P, Devulapalli C, Fu H, Carrier F, Bohr VA.

PLoS One. 2012;7(6):e35229. doi: 10.1371/journal.pone.0035229. Epub 2012 Jun 4.


The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.

Mason PA, Boubriak I, Robbins T, Lasala R, Saunders R, Cox LS.

Age (Dordr). 2013 Jun;35(3):793-806. doi: 10.1007/s11357-012-9411-0. Epub 2012 May 5.

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