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Items: 1 to 20 of 57


The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

Adams JM, Cory S.

Cell Death Differ. 2018 Jan;25(1):27-36. doi: 10.1038/cdd.2017.161. Epub 2017 Nov 3. Review.


Anti-apoptotic BCL-2 family members in development.

Opferman JT, Kothari A.

Cell Death Differ. 2018 Jan;25(1):37-45. doi: 10.1038/cdd.2017.170. Epub 2017 Nov 3. Review.


Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW.

Adams CM, Mitra R, Gong JZ, Eischen CM.

Clin Cancer Res. 2017 Nov 15;23(22):7119-7129. doi: 10.1158/1078-0432.CCR-17-1144. Epub 2017 Aug 29.


BCL-W has a fundamental role in B cell survival and lymphomagenesis.

Adams CM, Kim AS, Mitra R, Choi JK, Gong JZ, Eischen CM.

J Clin Invest. 2017 Feb 1;127(2):635-650. doi: 10.1172/JCI89486. Epub 2017 Jan 17.


Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ.

Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156. Epub 2017 Jan 13.


BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells.

Maes ME, Schlamp CL, Nickells RW.

Prog Retin Eye Res. 2017 Mar;57:1-25. doi: 10.1016/j.preteyeres.2017.01.002. Epub 2017 Jan 4. Review.


MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM.

Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237.


Targeting BCL2-Proteins for the Treatment of Solid Tumours.

Vogler M.

Adv Med. 2014;2014:943648. doi: 10.1155/2014/943648. Epub 2014 Aug 27. Review.


Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members.

Opferman JT.

FEBS J. 2016 Jul;283(14):2661-75. doi: 10.1111/febs.13472. Epub 2015 Sep 15. Review.


Mcl-1 is a key regulator of the ovarian reserve.

Omari S, Waters M, Naranian T, Kim K, Perumalsamy AL, Chi M, Greenblatt E, Moley KH, Opferman JT, Jurisicova A.

Cell Death Dis. 2015 May 7;6:e1755. doi: 10.1038/cddis.2015.95.


Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.

Sochalska M, Tuzlak S, Egle A, Villunger A.

FEBS J. 2015 Mar;282(5):834-849. doi: 10.1111/febs.13188. Epub 2015 Jan 23. Review.


Anti-apoptotic BCL-2 family proteins in acute neural injury.

Anilkumar U, Prehn JH.

Front Cell Neurosci. 2014 Sep 30;8:281. doi: 10.3389/fncel.2014.00281. eCollection 2014. Review.


ModuleRole: a tool for modulization, role determination and visualization in protein-protein interaction networks.

Li G, Li M, Zhang Y, Wang D, Li R, GuimerĂ  R, Gao JT, Zhang MQ.

PLoS One. 2014 May 1;9(5):e94608. doi: 10.1371/journal.pone.0094608. eCollection 2014.


Regulation of the autophagic bcl-2/beclin 1 interaction.

Decuypere JP, Parys JB, Bultynck G.

Cells. 2012 Jul 6;1(3):284-312. doi: 10.3390/cells1030284.


Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

Okamoto T, Coultas L, Metcalf D, van Delft MF, Glaser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Huang DC.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6. doi: 10.1073/pnas.1321259110. Epub 2013 Dec 20.


Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia.

Patel V, Chen LS, Wierda WG, Balakrishnan K, Gandhi V.

Leuk Lymphoma. 2014 Apr;55(4):899-910. doi: 10.3109/10428194.2013.819573. Epub 2013 Sep 10.


Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cells.

Bi J, Li Y, Sun F, Saalbach A, Klein C, Miller DJ, Hess R, Nowak RA.

Dev Biol. 2013 Aug 15;380(2):145-56. doi: 10.1016/j.ydbio.2013.05.023. Epub 2013 May 28.


Mechanisms of chemoresistance in cancer stem cells.

Abdullah LN, Chow EK.

Clin Transl Med. 2013 Jan 17;2(1):3. doi: 10.1186/2001-1326-2-3.


Delving deeper: MCL-1's contributions to normal and cancer biology.

Perciavalle RM, Opferman JT.

Trends Cell Biol. 2013 Jan;23(1):22-9. doi: 10.1016/j.tcb.2012.08.011. Epub 2012 Sep 28. Review.


Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.

Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.

Cell Death Differ. 2012 Nov;19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13.

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