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Items: 1 to 20 of 114

1.

Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells.

Cheng L, Liu YY, Lu PH, Peng Y, Yuan Q, Gu XS, Jin Y, Chen MB, Bai XM.

Oncotarget. 2017 Apr 25;8(17):28385-28394. doi: 10.18632/oncotarget.16073.

2.

DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

Enriquez-Rios V, Dumitrache LC, Downing SM, Li Y, Brown EJ, Russell HR, McKinnon PJ.

J Neurosci. 2017 Jan 25;37(4):893-905. doi: 10.1523/JNEUROSCI.4213-15.2017.

PMID:
28123024
3.

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells.

Zhen YF, Li ST, Zhu YR, Wang XD, Zhou XZ, Zhu LQ.

Oncotarget. 2016 Nov 29;7(48):79417-79427. doi: 10.18632/oncotarget.12712.

4.

XRN2 Links Transcription Termination to DNA Damage and Replication Stress.

Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA.

PLoS Genet. 2016 Jul 20;12(7):e1006107. doi: 10.1371/journal.pgen.1006107. eCollection 2016 Jul.

5.

Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation.

Zheng B, Mao JH, Li XQ, Qian L, Zhu H, Gu DH, Pan XD.

Sci Rep. 2016 Jul 14;6:29415. doi: 10.1038/srep29415.

6.

DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts.

Ahmed EA, Vélaz E, Rosemann M, Gilbertz KP, Scherthan H.

Chromosoma. 2017 Mar;126(2):287-298. doi: 10.1007/s00412-016-0590-9. Epub 2016 May 2.

7.

KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms.

Chen MB, Zhou ZT, Yang L, Wei MX, Tang M, Ruan TY, Xu JY, Zhou XZ, Chen G, Lu PH.

Oncotarget. 2016 Mar 29;7(13):17047-59. doi: 10.18632/oncotarget.7742.

8.

Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.

Neal JA, Xu Y, Abe M, Hendrickson E, Meek K.

J Immunol. 2016 Apr 1;196(7):3032-42. doi: 10.4049/jimmunol.1501654. Epub 2016 Feb 26.

9.

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

Hartlerode AJ, Morgan MJ, Wu Y, Buis J, Ferguson DO.

Nat Struct Mol Biol. 2015 Sep;22(9):736-43. doi: 10.1038/nsmb.3072. Epub 2015 Aug 17.

10.

Comparison of predicted and actual consequences of missense mutations.

Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, Andrews TD.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5189-98. doi: 10.1073/pnas.1511585112. Epub 2015 Aug 12.

11.

Targeting ATM-deficient CLL through interference with DNA repair pathways.

Knittel G, Liedgens P, Reinhardt HC.

Front Genet. 2015 Jun 10;6:207. doi: 10.3389/fgene.2015.00207. eCollection 2015. Review.

12.

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S.

Mol Cell. 2015 Apr 2;58(1):172-85. doi: 10.1016/j.molcel.2015.02.024. Epub 2015 Mar 26.

13.

Double-strand break repair on sex chromosomes: challenges during male meiotic prophase.

Lu LY, Yu X.

Cell Cycle. 2015;14(4):516-25. doi: 10.1080/15384101.2014.998070. Review.

14.

Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.

Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, Batalov S, Harris JL, Liu J.

BMC Cancer. 2014 Dec 13;14:944. doi: 10.1186/1471-2407-14-944.

15.

DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency.

Ghonim MA, Pyakurel K, Ju J, Rodriguez PC, Lammi MR, Davis C, Abughazleh MQ, Mansy MS, Naura AS, Boulares AH.

J Allergy Clin Immunol. 2015 Feb;135(2):425-40. doi: 10.1016/j.jaci.2014.09.005. Epub 2014 Oct 19.

16.

53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.

Rybanska-Spaeder I, Ghosh R, Franco S.

PLoS One. 2014 Sep 29;9(9):e108731. doi: 10.1371/journal.pone.0108731. eCollection 2014.

17.

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P.

PLoS One. 2014 Apr 16;9(4):e93568. doi: 10.1371/journal.pone.0093568. eCollection 2014.

18.

Functional overlaps between XLF and the ATM-dependent DNA double strand break response.

Kumar V, Alt FW, Oksenych V.

DNA Repair (Amst). 2014 Apr;16:11-22. doi: 10.1016/j.dnarep.2014.01.010. Epub 2014 Feb 20. Review.

19.

Non-homologous end joining often uses microhomology: implications for alternative end joining.

Pannunzio NR, Li S, Watanabe G, Lieber MR.

DNA Repair (Amst). 2014 May;17:74-80. doi: 10.1016/j.dnarep.2014.02.006. Epub 2014 Mar 7. Review.

20.

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence.

Qing Y, Wang Z, Bunting KD, Gerson SL.

Blood. 2014 Feb 13;123(7):1002-11. doi: 10.1182/blood-2013-08-521716. Epub 2014 Jan 6.

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