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Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.

Pose-Utrilla J, García-Guerra L, Del Puerto A, Martín A, Jurado-Arjona J, De León-Reyes NS, Gamir-Morralla A, Serrano ÁS, García-Gallo M, Kremer L, Fielitz J, Ireson C, Pérez-Álvarez MJ, Ferrer I, Hernández F, Ávila J, Lasa M, Campanero MR, Iglesias T.

Nat Commun. 2017 Dec 22;8(1):2275. doi: 10.1038/s41467-017-02322-5.


Protein kinase D signaling in cancer: A friend or foe?

Roy A, Ye J, Deng F, Wang QJ.

Biochim Biophys Acta. 2017 Aug;1868(1):283-294. doi: 10.1016/j.bbcan.2017.05.008. Epub 2017 May 31. Review.


Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.

Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

J Biol Chem. 2017 Jun 9;292(23):9523-9539. doi: 10.1074/jbc.M116.771394. Epub 2017 Apr 13.


Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).

Wang J, Sinnett-Smith J, Stevens JV, Young SH, Rozengurt E.

J Biol Chem. 2016 Aug 19;291(34):17988-8005. doi: 10.1074/jbc.M115.711275. Epub 2016 Jul 1.


Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis.

Ren B.

Front Cell Dev Biol. 2016 May 4;4:37. doi: 10.3389/fcell.2016.00037. eCollection 2016. Review.


A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/β-catenin signaling in breast cancer.

Kim do Y, Park EY, Chang E, Kang HG, Koo Y, Lee EJ, Ko JY, Kong HK, Chun KH, Park JH.

Oncotarget. 2016 Mar 22;7(12):14791-802. doi: 10.18632/oncotarget.7443.


Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552.

Wang J, Han L, Sinnett-Smith J, Han LL, Stevens JV, Rozengurt N, Young SH, Rozengurt E.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C542-57. doi: 10.1152/ajpcell.00302.2015. Epub 2016 Jan 6.


Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.

Mazzeo C, Calvo V, Alonso R, Mérida I, Izquierdo M.

Cell Death Differ. 2016 Jan;23(1):99-109. doi: 10.1038/cdd.2015.72. Epub 2015 Jun 5.


Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro.

Varga A, Gyulavári P, Greff Z, Futosi K, Németh T, Simon-Szabó L, Kerekes K, Szántai-Kis C, Brauswetter D, Kokas M, Borbély G, Erdei A, Mócsai A, Kéri G, Vántus T.

PLoS One. 2015 Apr 14;10(4):e0124234. doi: 10.1371/journal.pone.0124234. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0144792.


The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice.

Venardos K, De Jong KA, Elkamie M, Connor T, McGee SL.

PLoS One. 2015 Mar 23;10(3):e0120934. doi: 10.1371/journal.pone.0120934. eCollection 2015.


Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.

Olala LO, Shapiro BA, Merchen TC, Wynn JJ, Bollag WB.

Mol Cell Endocrinol. 2014 Jul 5;392(1-2):173-81. doi: 10.1016/j.mce.2014.05.015. Epub 2014 May 22.


Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.

Döppler H, Bastea LI, Borges S, Spratley SJ, Pearce SE, Storz P.

PLoS One. 2014 May 19;9(5):e98090. doi: 10.1371/journal.pone.0098090. eCollection 2014.


Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412.

Sánchez-Ruiloba L, Aicart-Ramos C, García-Guerra L, Pose-Utrilla J, Rodríguez-Crespo I, Iglesias T.

PLoS One. 2014 Apr 16;9(4):e95191. doi: 10.1371/journal.pone.0095191. eCollection 2014.


Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system.

Li G, Wang Y.

Neurosci Bull. 2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13. Review.


PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.

Ni Y, Sinnett-Smith J, Young SH, Rozengurt E.

PLoS One. 2013 Sep 9;8(9):e73149. doi: 10.1371/journal.pone.0073149. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/70d3c7b0-9718-4bb1-abed-d0defc3b7fc4.


Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.

Rezaee F, DeSando SA, Ivanov AI, Chapman TJ, Knowlden SA, Beck LA, Georas SN.

J Virol. 2013 Oct;87(20):11088-95. doi: 10.1128/JVI.01573-13. Epub 2013 Aug 7.


A novel role of proteasomal β1 subunit in tumorigenesis.

Yuan F, Ma Y, You P, Lin W, Lu H, Yu Y, Wang X, Jiang J, Yang P, Ma Q, Tao T.

Biosci Rep. 2013 Jul 16;33(4). pii: e00050. doi: 10.1042/BSR20130013.


Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling.

Faulstich M, Böttcher JP, Meyer TF, Fraunholz M, Rudel T.

PLoS Pathog. 2013;9(5):e1003373. doi: 10.1371/journal.ppat.1003373. Epub 2013 May 23.


Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.

Waldron RT, Innamorati G, Torres-Marquez ME, Sinnett-Smith J, Rozengurt E.

Cell Signal. 2012 Apr;24(4):914-21. doi: 10.1016/j.cellsig.2011.12.014. Epub 2011 Dec 29.


Regulation of protein kinase D1 activity.

Steinberg SF.

Mol Pharmacol. 2012 Mar;81(3):284-91. doi: 10.1124/mol.111.075986. Epub 2011 Dec 21. Review.

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