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DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.

Wu KZ, Wang GN, Fitzgerald J, Quachthithu H, Rainey MD, Cattaneo A, Bachi A, Santocanale C.

Nucleic Acids Res. 2016 Oct 14;44(18):8786-8798. Epub 2016 Jul 12.


A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis.

Edgerton H, Johansson M, Keifenheim D, Mukherjee S, Chacón JM, Bachant J, Gardner MK, Clarke DJ.

J Cell Biol. 2016 Jun 20;213(6):651-64. doi: 10.1083/jcb.201511080.


The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells.

Liberio MS, Sadowski MC, Davis RA, Rockstroh A, Vasireddy R, Lehman ML, Nelson CC.

Oncotarget. 2015 Dec 22;6(41):43944-63. doi: 10.18632/oncotarget.6267.


Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.

Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB.

Curr Cancer Drug Targets. 2015;15(8):739-49. Review.


TOP2A amplification and overexpression in hepatocellular carcinoma tissues.

Panvichian R, Tantiwetrueangdet A, Angkathunyakul N, Leelaudomlipi S.

Biomed Res Int. 2015;2015:381602. doi: 10.1155/2015/381602. Epub 2015 Jan 28.


Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.

Ketron AC, Osheroff N.

Phytochem Rev. 2014 Mar 1;13(1):19-35.


The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells.

Farr CJ, Antoniou-Kourounioti M, Mimmack ML, Volkov A, Porter AC.

Nucleic Acids Res. 2014 Apr;42(7):4414-26. doi: 10.1093/nar/gku076. Epub 2014 Jan 29.


Nek2-targeted ASO or siRNA pretreatment enhances anticancer drug sensitivity in triple‑negative breast cancer cells.

Lee J, Gollahon L.

Int J Oncol. 2013 Mar;42(3):839-47. doi: 10.3892/ijo.2013.1788. Epub 2013 Jan 22.


Iron chelators with topoisomerase-inhibitory activity and their anticancer applications.

Rao VA.

Antioxid Redox Signal. 2013 Mar 10;18(8):930-55. doi: 10.1089/ars.2012.4877. Epub 2012 Oct 26. Review.


Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.

Grozav AG, Willard BB, Kozuki T, Chikamori K, Micluta MA, Petrescu AJ, Kinter M, Ganapathi R, Ganapathi MK.

Proteomics. 2011 Mar;11(5):829-42. doi: 10.1002/pmic.201000194. Epub 2011 Jan 31.


PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.

Ryu H, Furuta M, Kirkpatrick D, Gygi SP, Azuma Y.

J Cell Biol. 2010 Nov 15;191(4):783-94. doi: 10.1083/jcb.201004033.


Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei.

Obado SO, Bot C, Echeverry MC, Bayona JC, Alvarez VE, Taylor MC, Kelly JM.

Nucleic Acids Res. 2011 Feb;39(3):1023-33. doi: 10.1093/nar/gkq839. Epub 2010 Sep 22.


The use of divalent metal ions by type II topoisomerases.

Deweese JE, Osheroff N.

Metallomics. 2010 Jul;2(7):450-9. doi: 10.1039/c003759a. Epub 2010 May 21. Review.


The dynamics of DNA topoisomerase IIalpha in living cells.

Daum JR, Mo YY, Gorbsky GJ.

Methods Mol Biol. 2009;582:233-44. doi: 10.1007/978-1-60761-340-4_18.


Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy.

Albadine R, Wang W, Brownlee NA, Toubaji A, Billis A, Argani P, Epstein JI, Garvin AJ, Cousi R, Schaeffer EM, Pavlovich C, Netto GJ.

J Urol. 2009 Aug;182(2):735-40. doi: 10.1016/j.juro.2009.03.078. Epub 2009 Jun 18.


JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis.

Moon DO, Kim MO, Kang CH, Lee JD, Choi YH, Kim GY.

Exp Mol Med. 2009 Sep 30;41(9):665-77. doi: 10.3858/emm.2009.41.9.073.


DNA topoisomerase II and its growing repertoire of biological functions.

Nitiss JL.

Nat Rev Cancer. 2009 May;9(5):327-37. doi: 10.1038/nrc2608. Epub 2009 Apr 20. Review.


Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

Deweese JE, Burch AM, Burgin AB, Osheroff N.

Biochemistry. 2009 Mar 10;48(9):1862-9. doi: 10.1021/bi8023256.


Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain.

McClendon AK, Gentry AC, Dickey JS, Brinch M, Bendsen S, Andersen AH, Osheroff N.

Biochemistry. 2008 Dec 16;47(50):13169-78. doi: 10.1021/bi800453h.


The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.

Deweese JE, Osheroff N.

Nucleic Acids Res. 2009 Feb;37(3):738-48. doi: 10.1093/nar/gkn937. Epub 2008 Nov 28. Review.

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