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A current structural perspective on PXR and CAR in drug metabolism.

Buchman CD, Chai SC, Chen T.

Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):635-647. doi: 10.1080/17425255.2018.1476488. Epub 2018 May 30.


Defining a conformational ensemble that directs activation of PPARγ.

Chrisman IM, Nemetchek MD, de Vera IMS, Shang J, Heidari Z, Long Y, Reyes-Caballero H, Galindo-Murillo R, Cheatham TE 3rd, Blayo AL, Shin Y, Fuhrmann J, Griffin PR, Kamenecka TM, Kojetin DJ, Hughes TS.

Nat Commun. 2018 May 4;9(1):1794. doi: 10.1038/s41467-018-04176-x.


Ginsenoside Rg3 stereoisomers differentially inhibit vascular smooth muscle cell proliferation and migration in diabetic atherosclerosis.

Guo M, Guo G, Xiao J, Sheng X, Zhang X, Tie Y, Cheng YK, Ji X.

J Cell Mol Med. 2018 Jun;22(6):3202-3214. doi: 10.1111/jcmm.13601. Epub 2018 Mar 22.


Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties.

Ribeiro Filho HV, Bernardi Videira N, Bridi AV, Tittanegro TH, Helena Batista FA, de Carvalho Pereira JG, de Oliveira PSL, Bajgelman MC, Le Maire A, Figueira ACM.

Front Endocrinol (Lausanne). 2018 Feb 1;9:11. doi: 10.3389/fendo.2018.00011. eCollection 2018.


Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation.

Lee YK, Sohn JH, Han JS, Park YJ, Jeon YG, Ji Y, Dalen KT, Sztalryd C, Kimmel AR, Kim JB.

Diabetes. 2018 May;67(5):791-804. doi: 10.2337/db17-0983. Epub 2018 Feb 13.


Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice.

Penas FN, Carta D, Dmytrenko G, Mirkin GA, Modenutti CP, Cevey ÁC, Rada MJ, Ferlin MG, Sales ME, Goren NB.

Front Immunol. 2017 Dec 11;8:1738. doi: 10.3389/fimmu.2017.01738. eCollection 2017.


Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ.

Jang JY, Bae H, Lee YJ, Choi YI, Kim HJ, Park SB, Suh SW, Kim SW, Han BW.

Sci Rep. 2018 Jan 8;8(1):31. doi: 10.1038/s41598-017-18274-1.


Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs.

Lee MA, Tan L, Yang H, Im YG, Im YJ.

Sci Rep. 2017 Dec 4;7(1):16837. doi: 10.1038/s41598-017-17082-x.


Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.

Mohandas S, Vairappan B.

World J Hepatol. 2017 Nov 18;9(32):1210-1226. doi: 10.4254/wjh.v9.i32.1210. Review.


Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes.

Yasmin S, Capone F, Laghezza A, Piaz FD, Loiodice F, Vijayan V, Devadasan V, Mondal SK, Atlı Ö, Baysal M, Pattnaik AK, Jayaprakash V, Lavecchia A.

Sci Rep. 2017 Oct 31;7(1):14453. doi: 10.1038/s41598-017-14776-0.


Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ.

Pallauf K, Duckstein N, Hasler M, Klotz LO, Rimbach G.

Oxid Med Cell Longev. 2017;2017:4397340. doi: 10.1155/2017/4397340. Epub 2017 Jul 6.


Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer.

Jeong J, Park S, An HT, Kang M, Ko J.

PLoS One. 2017 Jun 29;12(6):e0180197. doi: 10.1371/journal.pone.0180197. eCollection 2017.


Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

Lempiäinen JK, Niskanen EA, Vuoti KM, Lampinen RE, Göös H, Varjosalo M, Palvimo JJ.

Mol Cell Proteomics. 2017 Aug;16(8):1462-1474. doi: 10.1074/mcp.M117.067488. Epub 2017 Jun 13.


Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ.

Moldes-Anaya A, Sæther T, Uhlig S, Nebb HI, Larsen T, Eilertsen HC, Paulsen SM.

Mar Drugs. 2017 May 25;15(6). pii: E148. doi: 10.3390/md15060148.


Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.

Li X, Anderson M, Collin D, Muegge I, Wan J, Brennan D, Kugler S, Terenzio D, Kennedy C, Lin S, Labadia ME, Cook B, Hughes R, Farrow NA.

J Biol Chem. 2017 Jul 14;292(28):11618-11630. doi: 10.1074/jbc.M117.789024. Epub 2017 May 25.


Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.

Frkic RL, He Y, Rodriguez BB, Chang MR, Kuruvilla D, Ciesla A, Abell AD, Kamenecka TM, Griffin PR, Bruning JB.

J Med Chem. 2017 Jun 8;60(11):4584-4593. doi: 10.1021/acs.jmedchem.6b01727. Epub 2017 May 22.


Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals.

Vogeler S, Galloway TS, Isupov M, Bean TP.

PLoS One. 2017 Apr 20;12(4):e0176024. doi: 10.1371/journal.pone.0176024. eCollection 2017.


Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ.

Mao H, Lockyer P, Li L, Ballantyne CM, Patterson C, Xie L, Pi X.

Nat Commun. 2017 Apr 10;8:14960. doi: 10.1038/ncomms14960.


Investigations on Binding Pattern of Kinase Inhibitors with PPARγ: Molecular Docking, Molecular Dynamic Simulations, and Free Energy Calculation Studies.

Mazumder M, Ponnan P, Das U, Gourinath S, Khan HA, Yang J, Sakharkar MK.

PPAR Res. 2017;2017:6397836. doi: 10.1155/2017/6397836. Epub 2017 Feb 22.

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