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The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells.

Corre I, Paris F, Huot J.

Oncotarget. 2017 May 29;8(33):55684-55714. doi: 10.18632/oncotarget.18264. eCollection 2017 Aug 15. Review.


Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.

Mazur SJ, Gallagher ES, Debnath S, Durell SR, Anderson KW, Miller Jenkins LM, Appella E, Hudgens JW.

Biochemistry. 2017 May 30;56(21):2676-2689. doi: 10.1021/acs.biochem.6b01220. Epub 2017 May 12.


Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.

Cheung PW, Ueberdiek L, Day J, Bouley R, Brown D.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F404-F413. doi: 10.1152/ajprenal.00004.2017. Epub 2017 Apr 5.


Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation.

Zhou Y, Zhao Y, Gao Y, Hu W, Qu Y, Lou N, Zhu Y, Zhang X, Yang H.

J Exp Clin Cancer Res. 2017 Mar 10;36(1):42. doi: 10.1186/s13046-017-0510-8.


Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis.

Schaaf K, Smith SR, Duverger A, Wagner F, Wolschendorf F, Westfall AO, Kutsch O, Sun J.

Sci Rep. 2017 Feb 8;7:42101. doi: 10.1038/srep42101.


Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis.

Chen Z, Wang L, Yao D, Yang T, Cao WM, Dou J, Pang JC, Guan S, Zhang H, Yu Y, Zhao Y, Wang Y, Xu X, Shi Y, Patel R, Zhang H, Vasudevan SA, Liu S, Yang J, Nuchtern JG.

Sci Rep. 2016 Dec 19;6:38011. doi: 10.1038/srep38011.


PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.

Xiang W, Zhang Q, Lin X, Wu S, Zhou Y, Meng F, Fan Y, Shen T, Xiao M, Xia Z, Zou J, Feng XH, Xu P.

Sci Adv. 2016 Jul 1;2(7):e1501889. doi: 10.1126/sciadv.1501889. eCollection 2016 Jul.


Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity.

Shuaib A, Hartwell A, Kiss-Toth E, Holcombe M.

PLoS One. 2016 May 31;11(5):e0156139. doi: 10.1371/journal.pone.0156139. eCollection 2016.


p38 MAP kinases in the heart.

Yokota T, Wang Y.

Gene. 2016 Jan 10;575(2 Pt 2):369-376. doi: 10.1016/j.gene.2015.09.030. Epub 2015 Sep 20. Review.


PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation.

Li Z, Liu G, Sun L, Teng Y, Guo X, Jia J, Sha J, Yang X, Chen D, Sun Q.

PLoS Pathog. 2015 Mar 27;11(3):e1004783. doi: 10.1371/journal.ppat.1004783. eCollection 2015 Mar.


The catalytic role of the M2 metal ion in PP2Cα.

Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X, Sun JP.

Sci Rep. 2015 Feb 24;5:8560. doi: 10.1038/srep08560.


Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway.

Geng J, Fan J, Ouyang Q, Zhang X, Zhang X, Yu J, Xu Z, Li Q, Yao X, Liu X, Zheng J.

Oncotarget. 2014 Jul 30;5(14):5700-11.


BRCA1 and Its Network of Interacting Partners.

Christou CM, Kyriacou K.

Biology (Basel). 2013 Jan 2;2(1):40-63. doi: 10.3390/biology2010040.


RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.

Baker ST, Opperman KJ, Tulgren ED, Turgeon SM, Bienvenut W, Grill B.

PLoS Genet. 2014 May 8;10(5):e1004297. doi: 10.1371/journal.pgen.1004297. eCollection 2014 May.


Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity.

Tanoue K, Miller Jenkins LM, Durell SR, Debnath S, Sakai H, Tagad HD, Ishida K, Appella E, Mazur SJ.

Biochemistry. 2013 Aug 27;52(34):5830-43. doi: 10.1021/bi4005649. Epub 2013 Aug 16.


Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.

Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W, Sun JP.

Sci Rep. 2013;3:2333. doi: 10.1038/srep02333.


GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression.

Yu Y, Li J, Wan Y, Lu J, Gao J, Huang C.

PLoS One. 2013;8(3):e57185. doi: 10.1371/journal.pone.0057185. Epub 2013 Mar 11.


CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma.

Shukla A, Edwards R, Yang Y, Hahn A, Folkers K, Ding J, Padmakumar VC, Cataisson C, Suh KS, Yuspa SH.

Oncogene. 2014 Feb 13;33(7):842-50. doi: 10.1038/onc.2013.18. Epub 2013 Feb 18.


Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.

Liu Y, Maxwell S, Feng T, Zhu X, Elston RC, Koyutürk M, Chance MR.

BMC Syst Biol. 2012;6 Suppl 3:S15. doi: 10.1186/1752-0509-6-S3-S15. Epub 2012 Dec 17.


A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.

Bose AK, Janes KA.

Mol Cell Proteomics. 2013 Mar;12(3):797-806. doi: 10.1074/mcp.O112.024059. Epub 2012 Dec 11.

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