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Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan.

Keil A, Hall SR, Körner M, Herrmann M, Schmid RA, Frese S.

Arthritis Res Ther. 2016 Oct 22;18(1):243.


topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB.

Dahmane N, Gadelle D, Delmas S, Criscuolo A, Eberhard S, Desnoues N, Collin S, Zhang H, Pommier Y, Forterre P, Sezonov G.

Nucleic Acids Res. 2016 Apr 7;44(6):2795-805. doi: 10.1093/nar/gkw097. Epub 2016 Feb 22.


Site-Specific Recombination by SSV2 Integrase: Substrate Requirement and Domain Functions.

Zhan Z, Zhou J, Huang L.

J Virol. 2015 Nov;89(21):10934-44. doi: 10.1128/JVI.01637-15. Epub 2015 Aug 19.


Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.

Balaña-Fouce R, Alvarez-Velilla R, Fernández-Prada C, García-Estrada C, Reguera RM.

Int J Parasitol Drugs Drug Resist. 2014 Aug 24;4(3):326-37. doi: 10.1016/j.ijpddr.2014.07.006. eCollection 2014 Dec. Review.


Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases.

Srivastav R, Kumar D, Grover A, Singh A, Manjasetty BA, Sharma R, Taneja B.

Nucleic Acids Res. 2014 Jul;42(12):7894-910. doi: 10.1093/nar/gku425. Epub 2014 May 30.


PprA contributes to Deinococcus radiodurans resistance to nalidixic acid, genome maintenance after DNA damage and interacts with deinococcal topoisomerases.

Kota S, Charaka VK, Ringgaard S, Waldor MK, Misra HS.

PLoS One. 2014 Jan 15;9(1):e85288. doi: 10.1371/journal.pone.0085288. eCollection 2014.


The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination.

Serre MC, El Arnaout T, Brooks MA, Durand D, Lisboa J, Lazar N, Raynal B, van Tilbeurgh H, Quevillon-Cheruel S.

PLoS One. 2013 May 7;8(5):e63010. doi: 10.1371/journal.pone.0063010. Print 2013.


Characterization of DNA topoisomerase-1 in Spodoptera exigua for toxicity evaluation of camptothecin and hydoxy-camptothecin.

Zhang L, Ma D, Zhang Y, He W, Yang J, Li C, Jiang H.

PLoS One. 2013;8(2):e56458. doi: 10.1371/journal.pone.0056458. Epub 2013 Feb 22.


Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification.

Yakovleva L, Shuman S.

Biochemistry. 2013 Feb 5;52(5):984-91. doi: 10.1021/bi301643h. Epub 2013 Jan 23.


Structure of yeast kinetochore Ndc10 DNA-binding domain reveals unexpected evolutionary relationship to tyrosine recombinases.

Perriches T, Singleton MR.

J Biol Chem. 2012 Feb 10;287(7):5173-9. doi: 10.1074/jbc.C111.318501. Epub 2012 Jan 3.


All tangled up: how cells direct, manage and exploit topoisomerase function.

Vos SM, Tretter EM, Schmidt BH, Berger JM.

Nat Rev Mol Cell Biol. 2011 Nov 23;12(12):827-41. doi: 10.1038/nrm3228. Review.


Free energy calculations reveal rotating-ratchet mechanism for DNA supercoil relaxation by topoisomerase IB and its inhibition.

Wereszczynski J, Andricioaei I.

Biophys J. 2010 Aug 4;99(3):869-78. doi: 10.1016/j.bpj.2010.04.077.


Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site.

Patel A, Yakovleva L, Shuman S, Mondragón A.

Structure. 2010 Jun 9;18(6):725-33. doi: 10.1016/j.str.2010.03.007.


Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate.

Kachroo AH, Ma CH, Rowley PA, Maciaszek AD, Guga P, Jayaram M.

Nucleic Acids Res. 2010 Oct;38(19):6589-601. doi: 10.1093/nar/gkq466. Epub 2010 May 28.


Requirements for catalysis in the Cre recombinase active site.

Gibb B, Gupta K, Ghosh K, Sharp R, Chen J, Van Duyne GD.

Nucleic Acids Res. 2010 Sep;38(17):5817-32. doi: 10.1093/nar/gkq384. Epub 2010 May 12.


Electrostatic suppression allows tyrosine site-specific recombination in the absence of a conserved catalytic arginine.

Rowley PA, Kachroo AH, Ma CH, Maciaszek AD, Guga P, Jayaram M.

J Biol Chem. 2010 Jul 23;285(30):22976-85. doi: 10.1074/jbc.M110.112292. Epub 2010 May 6.


Insights from the structure of a smallpox virus topoisomerase-DNA transition state mimic.

Perry K, Hwang Y, Bushman FD, Van Duyne GD.

Structure. 2010 Jan 13;18(1):127-37. doi: 10.1016/j.str.2009.10.020.


Homology-dependent interactions determine the order of strand exchange by IntDOT recombinase.

Laprise J, Yoneji S, Gardner JF.

Nucleic Acids Res. 2010 Jan;38(3):958-69. doi: 10.1093/nar/gkp927. Epub 2009 Dec 1.


Poxvirus proteomics and virus-host protein interactions.

Van Vliet K, Mohamed MR, Zhang L, Villa NY, Werden SJ, Liu J, McFadden G.

Microbiol Mol Biol Rev. 2009 Dec;73(4):730-49. doi: 10.1128/MMBR.00026-09. Review.


Diversity and evolution of chromatin proteins encoded by DNA viruses.

de Souza RF, Iyer LM, Aravind L.

Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):302-18. doi: 10.1016/j.bbagrm.2009.10.006. Epub 2009 Oct 28. Review.

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