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Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry.

Tsirigotaki A, Elzen RV, Veken PV, Lambeir AM, Economou A.

Sci Rep. 2017 May 26;7(1):2456. doi: 10.1038/s41598-017-02550-1.


Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor.

Nojima H, Kanou K, Terashi G, Takeda-Shitaka M, Inoue G, Atsuda K, Itoh C, Iguchi C, Matsubara H.

BMC Struct Biol. 2016 Aug 5;16:11. doi: 10.1186/s12900-016-0062-8.


Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.

Zhen EY, Jin Z, Ackermann BL, Thomas MK, Gutierrez JA.

Biochem J. 2016 Mar 1;473(5):605-14. doi: 10.1042/BJ20151085. Epub 2015 Dec 3.


The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis.

Waumans Y, Baerts L, Kehoe K, Lambeir AM, De Meester I.

Front Immunol. 2015 Aug 7;6:387. doi: 10.3389/fimmu.2015.00387. eCollection 2015. Review.


The development of bioactive peptides from dietary proteins as a dipeptidyl peptidase IV inhibitor for the management of type 2 diabetes.

Jao CL, Hung CC, Tung YS, Lin PY, Chen MC, Hsu KC.

Biomedicine (Taipei). 2015 Sep;5(3):14. doi: 10.7603/s40681-015-0014-9. Epub 2015 Aug 13.


Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.

Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M.

PLoS Negl Trop Dis. 2015 Jun 3;9(6):e0003827. doi: 10.1371/journal.pntd.0003827. eCollection 2015.


The matrikine PGP as a potential biomarker in COPD.

Abdul Roda M, Fernstrand AM, Redegeld FA, Blalock JE, Gaggar A, Folkerts G.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1095-101. doi: 10.1152/ajplung.00040.2015. Epub 2015 Apr 10. Review.


Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site.

Iyer S, La-Borde PJ, Payne KA, Parsons MR, Turner AJ, Isaac RE, Acharya KR.

FEBS Open Bio. 2015 Apr 2;5:292-302. doi: 10.1016/j.fob.2015.03.013. eCollection 2015.


Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates.

Debnath S, Addya S.

Springerplus. 2014 Nov 6;3:660. doi: 10.1186/2193-1801-3-660. eCollection 2014.


Distribution, classification, domain architectures and evolution of prolyl oligopeptidases in prokaryotic lineages.

Kaushik S, Sowdhamini R.

BMC Genomics. 2014 Nov 18;15:985. doi: 10.1186/1471-2164-15-985.


Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers.

Dahan A, Wolk O, Yang P, Mittal S, Wu Z, Landowski CP, Amidon GL.

Mol Pharm. 2014 Dec 1;11(12):4385-94. doi: 10.1021/mp500483v. Epub 2014 Nov 13.


Proteomic analysis of embryogenesis and the acquisition of seed dormancy in Norway maple (Acer platanoides L.).

Staszak AM, Pawłowski TA.

Int J Mol Sci. 2014 Jun 17;15(6):10868-91. doi: 10.3390/ijms150610868.


A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.

Hensbergen PJ, Klychnikov OI, Bakker D, van Winden VJ, Ras N, Kemp AC, Cordfunke RA, Dragan I, Deelder AM, Kuijper EJ, Corver J, Drijfhout JW, van Leeuwen HC.

Mol Cell Proteomics. 2014 May;13(5):1231-44. doi: 10.1074/mcp.M113.034728. Epub 2014 Mar 12.


Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia.

Yang Y, Zhang YG, Lin GA, Xie HQ, Pan HT, Huang BQ, Liu JD, Liu H, Zhang N, Li L, Chen JH.

PLoS One. 2014 Feb 24;9(2):e89583. doi: 10.1371/journal.pone.0089583. eCollection 2014.


Ex vivo processing for maturation of Arabidopsis KDEL-tailed cysteine endopeptidase 2 (AtCEP2) pro-enzyme and its storage in endoplasmic reticulum derived organelles.

Hierl G, Höwing T, Isono E, Lottspeich F, Gietl C.

Plant Mol Biol. 2014 Apr;84(6):605-20. doi: 10.1007/s11103-013-0157-6. Epub 2013 Nov 28.


OsPOP5, a prolyl oligopeptidase family gene from rice confers abiotic stress tolerance in Escherichia coli.

Tan CM, Chen RJ, Zhang JH, Gao XL, Li LH, Wang PR, Deng XJ, Xu ZJ.

Int J Mol Sci. 2013 Oct 10;14(10):20204-19. doi: 10.3390/ijms141020204.


Validation of reference genes for normalization of qPCR gene expression data from Coffea spp. hypocotyls inoculated with Colletotrichum kahawae.

Figueiredo A, Loureiro A, Batista D, Monteiro F, Várzea V, Pais MS, Gichuru EK, Silva MC.

BMC Res Notes. 2013 Sep 28;6:388. doi: 10.1186/1756-0500-6-388.


Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV.

Ustün-Aytekin O, Gürhan ID, Ohura K, Imai T, Ongen G.

Cytotechnology. 2014 Jan;66(1):159-68. doi: 10.1007/s10616-013-9549-3. Epub 2013 May 29.


Production, active staining and gas chromatography assay analysis of recombinant aminopeptidase P from Lactococcus lactis ssp. lactis DSM 20481.

Stressler T, Eisele T, Schlayer M, Fischer L.

AMB Express. 2012 Aug 1;2(1):39. doi: 10.1186/2191-0855-2-39.


Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory.

D'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S.

Cereb Cortex. 2013 Aug;23(8):2007-14. doi: 10.1093/cercor/bhs199. Epub 2012 Jul 5.

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