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Items: 1 to 20 of 33


Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions.

Wang ZJ, Tabakoff B, Levinson SR, Heinbockel T.

Acta Pharmacol Sin. 2015 Jul;36(7):791-9. doi: 10.1038/aps.2015.26. Epub 2015 Jun 8.


Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties.

Park KD, Yang XF, Lee H, Dustrude ET, Wang Y, Khanna R, Kohn H.

ACS Chem Neurosci. 2013 Mar 20;4(3):463-74. doi: 10.1021/cn300188h. Epub 2013 Jan 16.


Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons.

Hildebrand ME, Mezeyova J, Smith PL, Salter MW, Tringham E, Snutch TP.

Mol Pain. 2011 Sep 12;7:67. doi: 10.1186/1744-8069-7-67.


Inhibition of neuronal voltage-gated sodium channels by brilliant blue G.

Jo S, Bean BP.

Mol Pharmacol. 2011 Aug;80(2):247-57. doi: 10.1124/mol.110.070276. Epub 2011 May 2.


Sodium channelopathies of skeletal muscle result from gain or loss of function.

Jurkat-Rott K, Holzherr B, Fauler M, Lehmann-Horn F.

Pflugers Arch. 2010 Jul;460(2):239-48. doi: 10.1007/s00424-010-0814-4. Epub 2010 Mar 17. Review.


Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.

Sheets MF, Hanck DA.

J Physiol. 2007 Jul 1;582(Pt 1):317-34. Epub 2007 May 17.


Sodium channels: ionic model of slow inactivation and state-dependent drug binding.

Tikhonov DB, Zhorov BS.

Biophys J. 2007 Sep 1;93(5):1557-70. Epub 2007 May 11.


Voltage-gated sodium channel modulation by scorpion alpha-toxins.

Bosmans F, Tytgat J.

Toxicon. 2007 Feb;49(2):142-58. Epub 2006 Sep 28. Review.


Rapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factor.

Talon S, Giroux-Metges MA, Pennec JP, Guillet C, Gascan H, Gioux M.

J Physiol. 2005 Jun 15;565(Pt 3):827-41. Epub 2005 Apr 14.


Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.

Sheets MF, Hanck DA.

J Physiol. 2005 Feb 15;563(Pt 1):83-93. Epub 2004 Dec 2.


Functional characterization and cold sensitivity of T1313A, a new mutation of the skeletal muscle sodium channel causing paramyotonia congenita in humans.

Bouhours M, Sternberg D, Davoine CS, Ferrer X, Willer JC, Fontaine B, Tabti N.

J Physiol. 2004 Feb 1;554(Pt 3):635-47. Epub 2003 Nov 14.


Molecular action of lidocaine on the voltage sensors of sodium channels.

Sheets MF, Hanck DA.

J Gen Physiol. 2003 Feb;121(2):163-75.


Movement and crevices around a sodium channel S3 segment.

Nguyen TP, Horn R.

J Gen Physiol. 2002 Sep;120(3):419-36.


Role of the C-terminal domain in inactivation of brain and cardiac sodium channels.

Mantegazza M, Yu FH, Catterall WA, Scheuer T.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15348-53. Epub 2001 Dec 11.


Protective effects of lactic acid on force production in rat skeletal muscle.

Nielsen OB, de Paoli F, Overgaard K.

J Physiol. 2001 Oct 1;536(Pt 1):161-6.


Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxin.

Cestèle S, Scheuer T, Mantegazza M, Rochat H, Catterall WA.

J Gen Physiol. 2001 Sep;118(3):291-302.


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