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The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.

Preston GM, Brodsky JL.

Biochem J. 2017 Feb 15;474(4):445-469. doi: 10.1042/BCJ20160582. Review.


Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.

Smith N, Adle DJ, Zhao M, Qin X, Kim H, Lee J.

J Biol Chem. 2016 Jul 15;291(29):15082-92. doi: 10.1074/jbc.M116.726265. Epub 2016 May 12.


Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae.

Buchanan BW, Lloyd ME, Engle SM, Rubenstein EM.

J Vis Exp. 2016 Apr 18;(110). doi: 10.3791/53975.


A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins.

Pfeiffer A, Stephanowitz H, Krause E, Volkwein C, Hirsch C, Jarosch E, Sommer T.

J Biol Chem. 2016 Jun 3;291(23):12195-207. doi: 10.1074/jbc.M115.703256. Epub 2016 Apr 6.


The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.

Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1438-49. doi: 10.1128/AAC.02239-15.


Delayed Turnover of Unphosphorylated Ssk1 during Carbon Stress Activates the Yeast Hog1 Map Kinase Pathway.

Vallejo MC, Mayinger P.

PLoS One. 2015 Sep 4;10(9):e0137199. doi: 10.1371/journal.pone.0137199. eCollection 2015.


Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases.

Cohen I, Wiener R, Reiss Y, Ravid T.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E625-32. doi: 10.1073/pnas.1415621112. Epub 2015 Feb 2.


Protein quality control at the inner nuclear membrane.

Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G, Ljungdahl PO, Knop M.

Nature. 2014 Dec 18;516(7531):410-3. doi: 10.1038/nature14096.


Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.

Boban M, Ljungdahl PO, Foisner R.

J Biol Chem. 2015 Jan 23;290(4):2489-95. doi: 10.1074/jbc.M114.600593. Epub 2014 Dec 9.


The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.

Mehnert M, Sommermeyer F, Berger M, Kumar Lakshmipathy S, Gauss R, Aebi M, Jarosch E, Sommer T.

Mol Biol Cell. 2015 Jan 15;26(2):185-94. doi: 10.1091/mbc.E14-07-1202. Epub 2014 Nov 26.


Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.

Zattas D, Hochstrasser M.

Crit Rev Biochem Mol Biol. 2015 Jan-Feb;50(1):1-17. doi: 10.3109/10409238.2014.959889. Epub 2014 Sep 18. Review.


Key steps in ERAD of luminal ER proteins reconstituted with purified components.

Stein A, Ruggiano A, Carvalho P, Rapoport TA.

Cell. 2014 Sep 11;158(6):1375-88. doi: 10.1016/j.cell.2014.07.050.


The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor.

El Magraoui F, Schrötter A, Brinkmeier R, Kunst L, Mastalski T, Müller T, Marcus K, Meyer HE, Girzalsky W, Erdmann R, Platta HW.

PLoS One. 2014 Aug 27;9(8):e105894. doi: 10.1371/journal.pone.0105894. eCollection 2014.


The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function.

Nakamura N.

Membranes (Basel). 2011 Dec 9;1(4):354-93. doi: 10.3390/membranes1040354.


Recent technical developments in the study of ER-associated degradation.

Nakatsukasa K, Kamura T, Brodsky JL.

Curr Opin Cell Biol. 2014 Aug;29:82-91. doi: 10.1016/ Epub 2014 May 24. Review.


RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.

Metzger MB, Pruneda JN, Klevit RE, Weissman AM.

Biochim Biophys Acta. 2014 Jan;1843(1):47-60. doi: 10.1016/j.bbamcr.2013.05.026. Epub 2013 Jun 6. Review.


A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms.

Metzger MB, Liang YH, Das R, Mariano J, Li S, Li J, Kostova Z, Byrd RA, Ji X, Weissman AM.

Mol Cell. 2013 May 23;50(4):516-27. doi: 10.1016/j.molcel.2013.04.004. Epub 2013 May 9.


N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.


The endoplasmic reticulum-associated degradation pathways of budding yeast.

Thibault G, Ng DT.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a013193. doi: 10.1101/cshperspect.a013193. Review.


The ubiquitin-proteasome system of Saccharomyces cerevisiae.

Finley D, Ulrich HD, Sommer T, Kaiser P.

Genetics. 2012 Oct;192(2):319-60. doi: 10.1534/genetics.112.140467. Review.

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