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T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.

Wang XF, Barbier E, Chiu YT, He Y, Zhan J, Bi GH, Zhang HY, Feng B, Liu-Chen LY, Wang JB, Xi ZX.

J Neurosci. 2016 Oct 5;36(40):10392-10403.


4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies.

Ikome HN, Ntie-Kang F, Ngemenya MN, Tu Z, Mach RH, Efange SM.

Chem Cent J. 2016 Aug 23;10(1):53. doi: 10.1186/s13065-016-0200-1.


Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.

Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G.

Mol Endocrinol. 2015 Nov;29(11):1619-33. doi: 10.1210/me.2015-1071.


Opioid receptor desensitization: mechanisms and its link to tolerance.

Allouche S, Noble F, Marie N.

Front Pharmacol. 2014 Dec 18;5:280. doi: 10.3389/fphar.2014.00280. Review.


Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord.

Brewer KL, Baran CA, Whitfield BR, Jensen AM, Clemens S.

Front Neural Circuits. 2014 Jun 11;8:62. doi: 10.3389/fncir.2014.00062.


Different mechanisms of homologous and heterologous μ-opioid receptor phosphorylation.

Mann A, Illing S, Miess E, Schulz S.

Br J Pharmacol. 2015 Jan;172(2):311-6. doi: 10.1111/bph.12627. Review.


Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.

Jaremko KM, Thompson NL Jr, Reyes BA, Jin J, Ebersole B, Jenney CB, Grigson PS, Levenson R, Berrettini WH, Van Bockstaele EJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:53-65. doi: 10.1016/j.pnpbp.2013.12.003.


Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize.

Granell S, Molden BM, Baldini G.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4733-42. doi: 10.1073/pnas.1219808110.


Ligand-induced μ opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanyl.

Anselmi L, Jaramillo I, Palacios M, Huynh J, Sternini C.

J Neurosci Res. 2013 Jun;91(6):854-60. doi: 10.1002/jnr.23214.


Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ.

Pharmacol Rev. 2013 Jan 15;65(1):223-54. doi: 10.1124/pr.112.005942. Review.


Endomorphin-2: a biased agonist at the μ-opioid receptor.

Rivero G, Llorente J, McPherson J, Cooke A, Mundell SJ, McArdle CA, Rosethorne EM, Charlton SJ, Krasel C, Bailey CP, Henderson G, Kelly E.

Mol Pharmacol. 2012 Aug;82(2):178-88. doi: 10.1124/mol.112.078659.


Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.

Raehal KM, Schmid CL, Groer CE, Bohn LM.

Pharmacol Rev. 2011 Dec;63(4):1001-19. doi: 10.1124/pr.111.004598. Review.


Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection.

Lau EK, Trester-Zedlitz M, Trinidad JC, Kotowski SJ, Krutchinsky AN, Burlingame AL, von Zastrow M.

Sci Signal. 2011 Aug 9;4(185):ra52. doi: 10.1126/scisignal.2001748.


A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.

Huang P, Chen C, Mague SD, Blendy JA, Liu-Chen LY.

Biochem J. 2012 Jan 1;441(1):379-86. doi: 10.1042/BJ20111050.


Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human.

Morgan MM, Christie MJ.

Br J Pharmacol. 2011 Oct;164(4):1322-34. doi: 10.1111/j.1476-5381.2011.01335.x. Review.


Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.

Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT.

J Neurosci. 2011 Mar 23;31(12):4434-43. doi: 10.1523/JNEUROSCI.4874-10.2011.


Protein kinase C-mediated phosphorylation of the μ-opioid receptor and its effects on receptor signaling.

Feng B, Li Z, Wang JB.

Mol Pharmacol. 2011 Apr;79(4):768-75. doi: 10.1124/mol.110.069096.


Therapeutic potential of β-arrestin- and G protein-biased agonists.

Whalen EJ, Rajagopal S, Lefkowitz RJ.

Trends Mol Med. 2011 Mar;17(3):126-39. doi: 10.1016/j.molmed.2010.11.004. Review.

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