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Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.

Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T.

Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y.


Exploring the model of PC12 apoptosis induced by OGSD/R through in vitro experiments.

Sun Y, Zhu W, Zhou S, Wang Z, Chen X, Jia L.

Oncotarget. 2017 Oct 4;8(52):90176-90184. doi: 10.18632/oncotarget.21623. eCollection 2017 Oct 27.


Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.

Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S, Lieberman J.

Cell. 2017 Nov 16;171(5):1125-1137.e11. doi: 10.1016/j.cell.2017.10.004. Epub 2017 Oct 26.


Death begets a new beginning.

Bosurgi L, Hughes LD, Rothlin CV, Ghosh S.

Immunol Rev. 2017 Nov;280(1):8-25. doi: 10.1111/imr.12585. Review.


Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.

Mascarenhas DPA, Cerqueira DM, Pereira MSF, Castanheira FVS, Fernandes TD, Manin GZ, Cunha LD, Zamboni DS.

PLoS Pathog. 2017 Aug 3;13(8):e1006502. doi: 10.1371/journal.ppat.1006502. eCollection 2017 Aug.


Caspase-2 mediates triglyceride (TG)-induced macrophage cell death.

Lim J, Kim HK, Kim SH, Rhee KJ, Kim YS.

BMB Rep. 2017 Oct;50(10):510-515.


Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain.

Vidmar R, Vizovišek M, Turk D, Turk B, Fonović M.

EMBO J. 2017 Aug 15;36(16):2455-2465. doi: 10.15252/embj.201796750. Epub 2017 Jul 21.


Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening.

Brantley SJ, Cotten SW, Lamson DR, Smith GR, Liu R, Williams KP.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):773-779. doi: 10.1016/j.bbrc.2017.07.100. Epub 2017 Jul 18.


Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.

Cabukusta B, Nettebrock NT, Kol M, Hilderink A, Tafesse FG, Holthuis JCM.

Biosci Rep. 2017 Jul 16;37(4). pii: BSR20170867. doi: 10.1042/BSR20170867. Print 2017 Aug 31.


Caspases and their substrates.

Julien O, Wells JA.

Cell Death Differ. 2017 Aug;24(8):1380-1389. doi: 10.1038/cdd.2017.44. Epub 2017 May 12. Review.


Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response.

Larimer BM, Wehrenberg-Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K, Boland G, Mahmood U.

Cancer Res. 2017 May 1;77(9):2318-2327. doi: 10.1158/0008-5472.CAN-16-3346.


Enzyme-triggered compound release using functionalized antimicrobial peptide derivatives.

Mizukami S, Kashibe M, Matsumoto K, Hori Y, Kikuchi K.

Chem Sci. 2017 Apr 1;8(4):3047-3053. doi: 10.1039/c6sc04435b. Epub 2017 Feb 20.


cybLuc: An Effective Aminoluciferin Derivative for Deep Bioluminescence Imaging.

Wu W, Su J, Tang C, Bai H, Ma Z, Zhang T, Yuan Z, Li Z, Zhou W, Zhang H, Liu Z, Wang Y, Zhou Y, Du L, Gu L, Li M.

Anal Chem. 2017 May 2;89(9):4808-4816. doi: 10.1021/acs.analchem.6b03510. Epub 2017 Apr 13.


Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity.

Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Stürzl M, Britzen-Laurent N.

J Cell Mol Med. 2017 Sep;21(9):1954-1966. doi: 10.1111/jcmm.13116. Epub 2017 Mar 8.


Identification of a direct Aquaporin-0 binding site in the lens-specific cytoskeletal protein filensin.

Wang Z, Schey KL.

Exp Eye Res. 2017 Jun;159:23-29. doi: 10.1016/j.exer.2017.02.012. Epub 2017 Mar 1.


Caspases play in traffic.

Duclos CM, Champagne A, Carrier JC, Saucier C, Lavoie CL, Denault JB.

Cell Death Dis. 2017 Mar 2;8(3):e2636. doi: 10.1038/cddis.2017.55. No abstract available.


Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.

Pakavathkumar P, Noël A, Lecrux C, Tubeleviciute-Aydin A, Hamel E, Ahlfors JE, LeBlanc AC.

Mol Neurodegener. 2017 Feb 28;12(1):22. doi: 10.1186/s13024-017-0166-z.


Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.

Sci Rep. 2017 Feb 23;7:43135. doi: 10.1038/srep43135.


Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.

Duclos CM, Champagne A, Carrier JC, Saucier C, Lavoie CL, Denault JB.

Cell Death Discov. 2017 Jan 23;3:16100. doi: 10.1038/cddiscovery.2016.100. eCollection 2017.


Interactome disassembly during apoptosis occurs independent of caspase cleavage.

Scott NE, Rogers LD, Prudova A, Brown NF, Fortelny N, Overall CM, Foster LJ.

Mol Syst Biol. 2017 Jan 12;13(1):906. doi: 10.15252/msb.20167067.

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