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Items: 1 to 20 of 106

1.

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels.

Proks P, Puljung MC, Vedovato N, Sachse G, Mulvaney R, Ashcroft FM.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150426. doi: 10.1098/rstb.2015.0426. Review. Erratum in: Philos Trans R Soc Lond B Biol Sci. 2016 Sep 5;371(1702). pii: 20160330. doi: 10.1098/rstb.2016.0330.

2.

Hyperinsulinemic Hypoglycemia - The Molecular Mechanisms.

Nessa A, Rahman SA, Hussain K.

Front Endocrinol (Lausanne). 2016 Mar 31;7:29. doi: 10.3389/fendo.2016.00029. Review.

3.

Sensitivity of KATP channels to cellular metabolic disorders and the underlying structural basis.

Li CG, Cui WY, Wang H.

Acta Pharmacol Sin. 2016 Jan;37(1):134-42. doi: 10.1038/aps.2015.134.

4.

The Nucleotide-Binding Sites of SUR1: A Mechanistic Model.

Vedovato N, Ashcroft FM, Puljung MC.

Biophys J. 2015 Dec 15;109(12):2452-60. doi: 10.1016/j.bpj.2015.10.026. Review.

5.

KATP Channels in the Cardiovascular System.

Foster MN, Coetzee WA.

Physiol Rev. 2016 Jan;96(1):177-252. doi: 10.1152/physrev.00003.2015. Review.

6.

Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues.

Principalli MA, Dupuis JP, Moreau CJ, Vivaudou M, Revilloud J.

Physiol Rep. 2015 Sep;3(9). pii: e12533. doi: 10.14814/phy2.12533.

7.

Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity.

Fatehi M, Carter CR, Youssef N, Hunter BE, Holt A, Light PE.

Biosci Rep. 2015 Jul 7;35(4). pii: e00238. doi: 10.1042/BSR20150143.

8.

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.

Proks P, de Wet H, Ashcroft FM.

J Gen Physiol. 2014 Nov;144(5):469-86. doi: 10.1085/jgp.201411222.

9.

The unusual stoichiometry of ADP activation of the KATP channel.

Hosy E, Vivaudou M.

Front Physiol. 2014 Jan 28;5:11. doi: 10.3389/fphys.2014.00011.

10.

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.

Martin GM, Chen PC, Devaraneni P, Shyng SL.

Front Physiol. 2013 Dec 24;4:386. doi: 10.3389/fphys.2013.00386. Review.

11.

The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.

Tinker A, Aziz Q, Thomas A.

Br J Pharmacol. 2014 Jan;171(1):12-23. doi: 10.1111/bph.12407. Review.

12.

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.

Pabreja K, Mohd MA, Koole C, Wootten D, Furness SG.

Br J Pharmacol. 2014 Mar;171(5):1114-28. doi: 10.1111/bph.12313. Review.

13.
14.

Neonatal diabetes caused by activating mutations in the sulphonylurea receptor.

Proks P.

Diabetes Metab J. 2013 Jun;37(3):157-64. doi: 10.4093/dmj.2013.37.3.157.

15.
16.

Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.

Fotinou C, Aittoniemi J, de Wet H, Polidori A, Pucci B, Sansom MS, Vénien-Bryan C, Ashcroft FM.

FEBS J. 2013 Feb;280(4):1051-63. doi: 10.1111/febs.12097.

17.
18.

The diabetic β-cell: hyperstimulated vs. hyperexcited.

Nichols CG, Remedi MS.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:129-35. doi: 10.1111/j.1463-1326.2012.01655.x. Review.

19.

Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes.

Fatima N, Schooley JF Jr, Claycomb WC, Flagg TP.

PLoS One. 2012;7(7):e41533. doi: 10.1371/journal.pone.0041533.

20.

A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.

de Wet H, Shimomura K, Aittoniemi J, Ahmad N, Lafond M, Sansom MS, Ashcroft FM.

J Physiol. 2012 Oct 15;590(20):5025-36. doi: 10.1113/jphysiol.2012.236075.

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