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Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function.

Chen C, Yang L, Villoutreix BO, Wang X, Ding Q, Rezaie AR.

Thromb Haemost. 2017 Jun 28;117(7):1358-1369. doi: 10.1160/TH17-01-0043. Epub 2017 Apr 13.


Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs.

Uversky VN.

Intrinsically Disord Proteins. 2014 Dec 12;2(1):e970499. doi: 10.4161/21690693.2014.970499. eCollection 2014.


Design and characterization of an APC-specific serpin for the treatment of hemophilia.

Polderdijk SG, Adams TE, Ivanciu L, Camire RM, Baglin TP, Huntington JA.

Blood. 2017 Jan 5;129(1):105-113. doi: 10.1182/blood-2016-05-718635. Epub 2016 Oct 27.


Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.

Gajsiewicz JM, Morrissey JH.

Semin Thromb Hemost. 2015 Oct;41(7):682-90. doi: 10.1055/s-0035-1564044. Epub 2015 Sep 26. Review.


Cytoprotective-selective activated protein C therapy for ischaemic stroke.

Mosnier LO, Zlokovic BV, Griffin JH.

Thromb Haemost. 2014 Nov;112(5):883-92. doi: 10.1160/TH14-05-0448. Epub 2014 Sep 18. Review.


Down-regulation of the clotting cascade by the protein C pathway.

Stavenuiter F, Bouwens EA, Mosnier LO.

Hematol Educ. 2013;7(1):365-374.


Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa.

Takeyama M, Wintermute JM, Manithody C, Rezaie AR, Fay PJ.

Biochemistry. 2013 Apr 2;52(13):2228-35. doi: 10.1021/bi301632g. Epub 2013 Mar 22.


Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.

Ding Q, Yang L, Hassanian SM, Rezaie AR.

Thromb Haemost. 2013 Apr;109(4):614-24. doi: 10.1160/TH12-10-0760. Epub 2013 Feb 7.


Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site.

Takeyama M, Wakabayashi H, Fay PJ.

Thromb Haemost. 2013 Feb;109(2):187-98. doi: 10.1160/TH12-08-0561. Epub 2012 Dec 6.


Protein C anticoagulant and cytoprotective pathways.

Griffin JH, Zlokovic BV, Mosnier LO.

Int J Hematol. 2012 Apr;95(4):333-45. doi: 10.1007/s12185-012-1059-0. Epub 2012 Apr 5. Review.


Proteases involved in cartilage matrix degradation in osteoarthritis.

Troeberg L, Nagase H.

Biochim Biophys Acta. 2012 Jan;1824(1):133-45. doi: 10.1016/j.bbapap.2011.06.020. Epub 2011 Jul 8. Review.


Capturing spontaneous partitioning of peripheral proteins using a biphasic membrane-mimetic model.

Arcario MJ, Ohkubo YZ, Tajkhorshid E.

J Phys Chem B. 2011 Jun 2;115(21):7029-37. doi: 10.1021/jp109631y. Epub 2011 May 11.


The role of P4-P3' residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa.

DeAngelis JP, Varfaj F, Wakabayashi H, Fay PJ.

Thromb Res. 2011 Nov;128(5):470-6. doi: 10.1016/j.thromres.2011.03.007. Epub 2011 Apr 5.


Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.

Cramer TJ, Gale AJ.

Br J Haematol. 2011 Jun;153(5):644-54. doi: 10.1111/j.1365-2141.2011.08657.x. Epub 2011 Apr 4.


Proteases as therapeutics.

Craik CS, Page MJ, Madison EL.

Biochem J. 2011 Apr 1;435(1):1-16. doi: 10.1042/BJ20100965. Review.


Cytoprotective protein C pathways and implications for stroke and neurological disorders.

Zlokovic BV, Griffin JH.

Trends Neurosci. 2011 Apr;34(4):198-209. doi: 10.1016/j.tins.2011.01.005. Epub 2011 Feb 25. Review.


Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.

Ní Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ.

J Biol Chem. 2011 Jan 14;286(2):1323-30. doi: 10.1074/jbc.M110.159475. Epub 2010 Nov 2.


Inhibition of thrombin formation by active site mutated (S360A) activated protein C.

Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J.

J Biol Chem. 2010 Jul 23;285(30):22890-900. doi: 10.1074/jbc.M110.131029. Epub 2010 May 18.


Activated protein C action in inflammation.

Sarangi PP, Lee HW, Kim M.

Br J Haematol. 2010 Mar;148(6):817-33. doi: 10.1111/j.1365-2141.2009.08020.x. Epub 2009 Dec 8. Review.

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