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Items: 18


Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes.

Walker VJ, Griffin AP, Hammar DK, Hollenberg PF.

J Pharmacol Exp Ther. 2016 Jun;357(3):537-44. doi: 10.1124/jpet.116.232553.


The role of epoxyeicosatrienoic acids in the cardiovascular system.

Yang L, Mäki-Petäjä K, Cheriyan J, McEniery C, Wilkinson IB.

Br J Clin Pharmacol. 2015 Jul;80(1):28-44. doi: 10.1111/bcp.12603. Review.


Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.

Beloiartsev A, da Glória Rodrigues-Machado M, Zhou GL, Tan TC, Zazzeron L, Tainsh RE, Leyton P, Jones RC, Scherrer-Crosbie M, Zapol WM.

Am J Respir Cell Mol Biol. 2015 May;52(5):563-70. doi: 10.1165/rcmb.2013-0482OC.


Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.

Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD.

PLoS Genet. 2013 Nov;9(11):e1003950. doi: 10.1371/journal.pgen.1003950.


CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee DY, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH.

Antimicrob Agents Chemother. 2013 Nov;57(11):5448-56. doi: 10.1128/AAC.00843-13.


Roles of the epoxygenase CYP2J2 in the endothelium.

Askari A, Thomson SJ, Edin ML, Zeldin DC, Bishop-Bailey D.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:56-63. doi: 10.1016/j.prostaglandins.2013.02.003. Review.


Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily.

Graves JP, Edin ML, Bradbury JA, Gruzdev A, Cheng J, Lih FB, Masinde TA, Qu W, Clayton NP, Morrison JP, Tomer KB, Zeldin DC.

Drug Metab Dispos. 2013 Apr;41(4):763-73. doi: 10.1124/dmd.112.049429.


Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension.

Capdevila J, Wang W.

Curr Opin Nephrol Hypertens. 2013 Mar;22(2):163-9. doi: 10.1097/MNH.0b013e32835d911e. Review.


Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.

Wang L, Yin J, Nickles HT, Ranke H, Tabuchi A, Hoffmann J, Tabeling C, Barbosa-Sicard E, Chanson M, Kwak BR, Shin HS, Wu S, Isakson BE, Witzenrath M, de Wit C, Fleming I, Kuppe H, Kuebler WM.

J Clin Invest. 2012 Nov;122(11):4218-30. doi: 10.1172/JCI59176.


Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.

Lee CA, Jones JP 3rd, Katayama J, Kaspera R, Jiang Y, Freiwald S, Smith E, Walker GS, Totah RA.

Drug Metab Dispos. 2012 May;40(5):943-51. doi: 10.1124/dmd.111.043505.


EET signaling in cancer.

Panigrahy D, Greene ER, Pozzi A, Wang DW, Zeldin DC.

Cancer Metastasis Rev. 2011 Dec;30(3-4):525-40. doi: 10.1007/s10555-011-9315-y. Review.


Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury.

Townsley MI, Morisseau C, Hammock B, King JA.

Microcirculation. 2010 Feb;17(2):137-46. doi: 10.1111/j.1549-8719.2009.00013.x.


Unusual regioselectivity and active site topology of human cytochrome P450 2J2.

Lafite P, André F, Zeldin DC, Dansette PM, Mansuy D.

Biochemistry. 2007 Sep 11;46(36):10237-47.


Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

Lafite P, Dijols S, Zeldin DC, Dansette PM, Mansuy D.

Arch Biochem Biophys. 2007 Aug 15;464(2):155-68.


Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.

Lafite P, Dijols S, Buisson D, Macherey AC, Zeldin DC, Dansette PM, Mansuy D.

Bioorg Med Chem Lett. 2006 May 15;16(10):2777-80.


Role of activator protein-1 in the down-regulation of the human CYP2J2 gene in hypoxia.

Marden NY, Fiala-Beer E, Xiang SH, Murray M.

Biochem J. 2003 Aug 1;373(Pt 3):669-80.


Drug-metabolizing cytochrome P450s in the brain.

Miksys SL, Tyndale RF.

J Psychiatry Neurosci. 2002 Nov;27(6):406-15. Review.

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