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Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study.

Männikkö R, Wong L, Tester DJ, Thor MG, Sud R, Kullmann DM, Sweeney MG, Leu C, Sisodiya SM, FitzPatrick DR, Evans MJ, Jeffrey IJM, Tfelt-Hansen J, Cohen MC, Fleming PJ, Jaye A, Simpson MA, Ackerman MJ, Hanna MG, Behr ER, Matthews E.

Lancet. 2018 Apr 14;391(10129):1483-1492. doi: 10.1016/S0140-6736(18)30021-7. Epub 2018 Apr 5.


Substitutions of the S4DIV R2 residue (R1451) in NaV1.4 lead to complex forms of paramyotonia congenita and periodic paralyses.

Poulin H, Gosselin-Badaroudine P, Vicart S, Habbout K, Sternberg D, Giuliano S, Fontaine B, Bendahhou S, Nicole S, Chahine M.

Sci Rep. 2018 Feb 1;8(1):2041. doi: 10.1038/s41598-018-20468-0.


Sodium Channelopathies of Skeletal Muscle.

Cannon SC.

Handb Exp Pharmacol. 2017 Sep 23. doi: 10.1007/164_2017_52. [Epub ahead of print]


In vivo assessment of muscle membrane properties in the sodium channel myotonias.

Tan SV, Z'Graggen WJ, Hanna MG, Bostock H.

Muscle Nerve. 2018 Apr;57(4):586-594. doi: 10.1002/mus.25956. Epub 2017 Sep 23.


Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes.

Chadda KR, Jeevaratnam K, Lei M, Huang CL.

Pflugers Arch. 2017 Jun;469(5-6):629-641. doi: 10.1007/s00424-017-1959-1. Epub 2017 Mar 6. Review.


Mice with an NaV1.4 sodium channel null allele have latent myasthenia, without susceptibility to periodic paralysis.

Wu F, Mi W, Fu Y, Struyk A, Cannon SC.

Brain. 2016 Jun;139(Pt 6):1688-99. doi: 10.1093/brain/aww070. Epub 2016 Apr 5.


Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison.

Loussouarn G, Sternberg D, Nicole S, Marionneau C, Le Bouffant F, Toumaniantz G, Barc J, Malak OA, Fressart V, Péréon Y, Baró I, Charpentier F.

Front Pharmacol. 2016 Jan 14;6:314. doi: 10.3389/fphar.2015.00314. eCollection 2015. Review.


Voltage-gated sodium channels and cancer: is excitability their primary role?

Roger S, Gillet L, Le Guennec JY, Besson P.

Front Pharmacol. 2015 Jul 29;6:152. doi: 10.3389/fphar.2015.00152. eCollection 2015. Review.


On the multiple roles of the voltage gated sodium channel β1 subunit in genetic diseases.

Baroni D, Moran O.

Front Pharmacol. 2015 May 18;6:108. doi: 10.3389/fphar.2015.00108. eCollection 2015. Review.


Channelopathies of skeletal muscle excitability.

Cannon SC.

Compr Physiol. 2015 Apr;5(2):761-90. doi: 10.1002/cphy.c140062. Review.


Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.

Capes DL, Goldschen-Ohm MP, Arcisio-Miranda M, Bezanilla F, Chanda B.

J Gen Physiol. 2013 Aug;142(2):101-12. doi: 10.1085/jgp.201310998. Epub 2013 Jul 15.


Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy.

Lu J, Wang HZ, Jia Z, Zuckerman J, Lu Z, Guo Y, Boink GJ, Brink PR, Robinson RB, Entcheva E, Cohen IS.

J Cardiovasc Pharmacol. 2012 Jul;60(1):88-99. doi: 10.1097/FJC.0b013e3182588b00.


Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians.

Zhao J, Duprè N, Puymirat J, Chahine M.

J Physiol. 2012 Jun 1;590(11):2629-44. doi: 10.1113/jphysiol.2011.223461. Epub 2012 Jan 16.


A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia.

Kubota T, Roca X, Kimura T, Kokunai Y, Nishino I, Sakoda S, Krainer AR, Takahashi MP.

Hum Mutat. 2011 Jul;32(7):773-82. doi: 10.1002/humu.21501. Epub 2011 Apr 28.


Gating behaviour of sodium currents in adult mouse muscle recorded with an improved two-electrode voltage clamp.

Fu Y, Struyk A, Markin V, Cannon S.

J Physiol. 2011 Feb 1;589(Pt 3):525-46. doi: 10.1113/jphysiol.2010.199430. Epub 2010 Dec 6.


Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction.

Coronel R, Lau DH, Sosunov EA, Janse MJ, Danilo P Jr, Anyukhovsky EP, Wilms-Schopman FJ, Opthof T, Shlapakova IN, Ozgen N, Prestia K, Kryukova Y, Cohen IS, Robinson RB, Rosen MR.

Heart Rhythm. 2010 Aug;7(8):1104-10. doi: 10.1016/j.hrthm.2010.04.009. Epub 2010 Apr 10.


Sodium channelopathies of skeletal muscle result from gain or loss of function.

Jurkat-Rott K, Holzherr B, Fauler M, Lehmann-Horn F.

Pflugers Arch. 2010 Jul;460(2):239-48. doi: 10.1007/s00424-010-0814-4. Epub 2010 Mar 17. Review.


Cold-induced disruption of Na+ channel slow inactivation underlies paralysis in highly thermosensitive paramyotonia.

Carle T, Fournier E, Sternberg D, Fontaine B, Tabti N.

J Physiol. 2009 Apr 15;587(Pt 8):1705-14. doi: 10.1113/jphysiol.2008.165787. Epub 2009 Feb 16.


Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.

Lau DH, Clausen C, Sosunov EA, Shlapakova IN, Anyukhovsky EP, Danilo P Jr, Rosen TS, Kelly C, Duffy HS, Szabolcs MJ, Chen M, Robinson RB, Lu J, Kumari S, Cohen IS, Rosen MR.

Circulation. 2009 Jan 6;119(1):19-27. doi: 10.1161/CIRCULATIONAHA.108.809301. Epub 2008 Dec 22.


Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness.

Hayward LJ, Kim JS, Lee MY, Zhou H, Kim JW, Misra K, Salajegheh M, Wu FF, Matsuda C, Reid V, Cros D, Hoffman EP, Renaud JM, Cannon SC, Brown RH Jr.

J Clin Invest. 2008 Apr;118(4):1437-49. doi: 10.1172/JCI32638.

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